Figure 7

Visualization of the difference between K _m and ${\mathit{K}}_{\mathit{s}}^{\mathbf{\left(}\mathit{c}\mathbf{\right)}}$ for τ _a = 99 min and an assumed distribution volume ${\stackrel{\mathbf{̄}}{\mathit{V}}}_{\mathit{r}}\mathbf{=}\mathbf{0}\mathbf{.}\mathbf{53}$ ml/ml. In comparison with Figure 6, the systematic difference relative to the true K _m is mostly removed even when V _r deviates distinctly from the assumed value. Moving along the line, V _r  ≈ 0.55 ml/ml between K _m  = 1 and 4 ml/min/100ml corresponds approximately to the experimental data of Figure 2B.