Multimodality imaging using SPECT/CT and MRI and ligand functionalized 99mTc-labeled magnetic microbubbles

EJNMMI Research

Table 1 Percentage of radioactivity found in organs expressed as ROI/total counts and radioactivity/injected dose

MBs	ROI measurements as percentage of the total counts obtained from dynamic imaging			Total radioactivity in organs as percentage of injected dose
				11.7 min			1 h
	Lungs	Liver	Kidneys	Lungs	Liver	Kidneys	Lungs	Liver	Kidneys
Plain	69	25	3	67	32	2	59	36	8
DTPA	62	28	7	66	25	5	52	43	6
Chitosan	64	28	3	58	22	2	51	39	5
PMAA	58	34	8	57	35	4	48	43	7
NOTA	43	37	8	50	40	3	47	45	6
NOTA-SPION	56	24	8	51	23	4	60	20	6
NOTA-SPION(24 h, PI)	8	50	18				6^a	54^a	16^a
DTPA-SPION	93	4	1	89	6	1	65	38	7
DTPA-SPION(24 h, PI)	25	40	40				21^a	37^a	41^a