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EJNMMI Research
Figure 1 | EJNMMI Research

Figure 1

From: Profiling of hepatic clearance pathways of Pittsburgh compound B and human liver cytochrome p450 phenotyping

Figure 1

Percentage of PiB remaining after incubation in HLM and relative contributions to turnover. (A) % PiB remaining after 0 (black), 15 (dark gray) and 60 min (light gray) incubations at 1 μM substrate concentration with rhCYPs 1A2, 2C9, 2C19, 2D6, and 3A4. (B) Relative contributions to turnover of PiB based on unscaled rhCYP data. (C) Relative contributions to turnover of PiB after scaling for the relative abundances of CYPs in human liver, according to Rodrigues [10].

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