From: Nuclear imaging of inflammation: homing-associated molecules as targets
Target molecule | Imaging agent | Imaged condition | Reference |
---|---|---|---|
E-selectin | 111In- or 99mTc-labeled anti-E-selectin mAb or fragments of it | Arthritis of pig, a pig model of gout, patients with RA, patients with IBD | |
E-selectin | 99mTc-labeled E-selectin-binding peptide | Rat model of arthritis | [11] |
P-selectin | 99mTc-labeled F(Ab)2 fragment | Pulmonary embolism in beagle dog | [12] |
VCAM-1 | 123I-labeled VCAM-1 antibody | Colitis in rat | [13] |
VCAM-1 | 123I- and 99mTc-labeled peptides | Atherosclerosis in rabbit, atherosclerotic plaques in mice | |
18F-labeled tetrameric peptide | |||
ICAM-1 | 111In-labeled ICAM-1 antibody | Lung injury in rat | [16] |
Integrin αvβ3 | 18F-, 64Cu-, and 68Ga-labeled RGD peptides | Mouse model of chronic inflammation, acute and chronic model of inflammation in mice, atherosclerotic plaques in mice |