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Table 1 Endothelial adhesion molecule candidates for the nuclear imaging and currently available imaging agents

From: Nuclear imaging of inflammation: homing-associated molecules as targets

Target molecule

Imaging agent

Imaged condition

Reference

E-selectin

111In- or 99mTc-labeled anti-E-selectin mAb or fragments of it

Arthritis of pig, a pig model of gout, patients with RA, patients with IBD

[6–10]

E-selectin

99mTc-labeled E-selectin-binding peptide

Rat model of arthritis

[11]

P-selectin

99mTc-labeled F(Ab)2 fragment

Pulmonary embolism in beagle dog

[12]

VCAM-1

123I-labeled VCAM-1 antibody

Colitis in rat

[13]

VCAM-1

123I- and 99mTc-labeled peptides

Atherosclerosis in rabbit, atherosclerotic plaques in mice

[14, 15]

18F-labeled tetrameric peptide

ICAM-1

111In-labeled ICAM-1 antibody

Lung injury in rat

[16]

Integrin αvβ3

18F-, 64Cu-, and 68Ga-labeled RGD peptides

Mouse model of chronic inflammation, acute and chronic model of inflammation in mice, atherosclerotic plaques in mice

[17–20]