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Table 2 Biodistribution and tumor to non-target organ ratios for 64Cu/NOTA-monomer and 64Cu/NOTA-dimer 2

From: Comparative study of 64Cu/NOTA-[D-Tyr6,βAla11,Thi13,Nle14]BBN(6-14) monomer and dimers for prostate cancer PET imaging

Organ

64Cu/NOTA-monomer

64Cu/NOTA-dimer 2

 

30 min

30 min

120 min

 

Unblocked

Blocked a

Unblocked

Unblocked

Blocked a

Blood

1.35 ± 0.47

12.72 ± 3.42

3.13 ± 0.67

1.34 ± 0.15

3.32 ± 2.78

Plasma

2.48 ± 0.63

21.69 ± 6.16

5.27 ± 1.27

2.45 ± 0.27

6.14 ± 4.89

Adrenal

4.29 ± 1.13

16.57 ± 0.37

9.23 ± 5.01

11.56 ± 4.91

3.63 ± 2.43

Fat

0.65 ± 0.54

3.22 ± 4.29

1.86 ± 0.81

0.68 ± 0.61

3.46 ± 2.74

Kidney

10.42 ± 1.29

75.13 ± 36.20

17.02 ± 6.24

26.37 ± 8.13

23.00 ± 5.37

Spleen

1.63 ± 1.82

3.29 ± 0.16

5.31 ± 1.43

5.50 ± 2.61

3.31 ± 0.95

Pancreas

5.10 ± 2.50

4.57 ± 2.65

4.60 ± 0.57

13.35 ± 7.38

1.43 ± 0.61b

Liver

5.38 ± 8.12

8.12 ± 0.70

41.79 ± 5.58

23.11 ± 2.36

12.20 ± 2.78b

Heart

1.05 ± 0.91

4.65 ± 0.33

4.42 ± 1.59

2.68 ± 0.13

1.58 ± 0.80

Lungs

1.77 ± 1.28

14.26 ± 1.58

7.22 ± 2.73

5.07 ± 1.58

34.42 ± 23.31

Muscle

0.40 ± 0.33

3.45 ± 2.06

1.59 ± 1.16

1.13 ± 0.62

1.41 ± 0.98

Bone

0.43 ± 0.46

1.52 ± 0.58

0.78 ± 0.21

0.83 ± 0.19

1.15 ± 0.44

Brain

0.08 ± 0.07

0.63 ± 0.09

0.38 ± 0.06

0.22 ± 0.05

0.16 ± 0.09

Tumor

1.79 ± 0.46

4.82 ± 0.91

3.95 ± 0.26

6.28 ± 2.87

3.25 ± 1.15

Tumor/blood

1.49 ± 0.41

0.38 ± 0.01b

1.39 ± 0.30

4.09 ± 1.79

1.04 ± 0.60b

Tumor/muscle

7.42 ± 3.17

1.59 ± 0.44b

3.95 ± 1.98

4.46 ± 1.86

2.31 ± 1.46

Tumor/liver

2.07 ± 1.13

0.60 ± 0.13

0.10 ± 0.01

0.22 ± 0.07

0.24 ± 0.09

Tumor/kidney

0.17 ± 0.04

0.07 ± 0.01b

0.28 ± 0.09

0.22 ± 0.11

0.12 ± 0.03

Tumor/pancreas

0.44 ± 0.17

1.18 ± 0.32b

0.89 ± 0.11

0.36 ± 0.09

1.80 ± 0.39b

  1. Biodistribution and ratios are at 30 and 120 min post-injection. aBlocked by injecting 0.1 μmol of non-radiolabeled peptide together with the radiopeptide. bCo-injection significantly lowered the uptake of the same organ for the corresponding tracer (p < 0.05).