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Table 2 Rate constants of FDG parameters for manually drawn gray and white matter ROIs and literature values

From: Cerebral blood flow and glucose metabolism in healthy volunteers measured using a high-resolution PET scanner

 

FDG parameters

K i

K 1

K 2

k 3

k 4

Present study (3 K)

     

GM

0.031 ± 0.004

0.062 ± 0.008

0.071 ± 0.04

0.067 ± 0.03

n/a

WM

0.010 ± 0.0008

0.033 ± 0.004

0.083 ± 0.03

0.037 ± 0.01

n/a

GM/WM

3.0

1.9

0.87

1.8

n/a

Huang et al. (4 K) [3]

     

GM

0.0334 ± 0.006

0.102 ± 0.03

0.13 ± 0.07

0.062 ± 0.02

0.0068 ± 0.001

WM

0.0154 ± 0.004

0.054 ± 0.01

0.109 ± 0.04

0.045 ± 0.02

0.0058 ± 0.002

GM/WM

2.2

1.9

1.2

1.4

1.2

Reivich et al. (3 K) [29]

     

GM

0.035a

0.105 ± 0.006

0.148 ± 0.008

0.074 ± 0.005

n/a

WM

0.023a

0.069 ± 0.005

0.129 ± 0.004

0.064 ± 0.006

n/a

GM/WM

1.5

1.5

1.1

1.2

n/a

Reivich et al. (4 K) [29]

     

GM

0.034a

0.095 ± 0.005

0.125 ± 0.002

0.069 ± 0.002

0.0055 ± 0.0003

WM

0.022a

0.065 ± 0.005

0.126 ± 0.003

0.066 ± 0.002

0.0054 ± 0.0006

GM/WM

1.5

1.5

0.99

1.0

1.0

  1. Mean ± SD; data of the present study are obtained by NLR analyses based on BSIFs. 3 K, 3 k model (i.e., k 4 = 0); 4 K, 4 k parameter model; K i, net influx rate (in min-1); K 1, rate of transport from blood to brain (in min-1); k 2, rate of transport from brain to blood (in min-1); k 3, phosphorylation rate by hexokinase (in min-1); k 4, rate of hydrolysis by glucose-6-phosphatase (in min-1); GM, gray matter; WM, white matter; n/a, not applicable. aCalculated by the K 1, k 2, and k 3 parameters reported in the paper.