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Table 2 Rate constants of FDG parameters for manually drawn gray and white matter ROIs and literature values

From: Cerebral blood flow and glucose metabolism in healthy volunteers measured using a high-resolution PET scanner

  FDG parameters
K i K 1 K 2 k 3 k 4
Present study (3 K)      
GM 0.031 ± 0.004 0.062 ± 0.008 0.071 ± 0.04 0.067 ± 0.03 n/a
WM 0.010 ± 0.0008 0.033 ± 0.004 0.083 ± 0.03 0.037 ± 0.01 n/a
GM/WM 3.0 1.9 0.87 1.8 n/a
Huang et al. (4 K) [3]      
GM 0.0334 ± 0.006 0.102 ± 0.03 0.13 ± 0.07 0.062 ± 0.02 0.0068 ± 0.001
WM 0.0154 ± 0.004 0.054 ± 0.01 0.109 ± 0.04 0.045 ± 0.02 0.0058 ± 0.002
GM/WM 2.2 1.9 1.2 1.4 1.2
Reivich et al. (3 K) [29]      
GM 0.035a 0.105 ± 0.006 0.148 ± 0.008 0.074 ± 0.005 n/a
WM 0.023a 0.069 ± 0.005 0.129 ± 0.004 0.064 ± 0.006 n/a
GM/WM 1.5 1.5 1.1 1.2 n/a
Reivich et al. (4 K) [29]      
GM 0.034a 0.095 ± 0.005 0.125 ± 0.002 0.069 ± 0.002 0.0055 ± 0.0003
WM 0.022a 0.065 ± 0.005 0.126 ± 0.003 0.066 ± 0.002 0.0054 ± 0.0006
GM/WM 1.5 1.5 0.99 1.0 1.0
  1. Mean ± SD; data of the present study are obtained by NLR analyses based on BSIFs. 3 K, 3 k model (i.e., k 4 = 0); 4 K, 4 k parameter model; K i, net influx rate (in min-1); K 1, rate of transport from blood to brain (in min-1); k 2, rate of transport from brain to blood (in min-1); k 3, phosphorylation rate by hexokinase (in min-1); k 4, rate of hydrolysis by glucose-6-phosphatase (in min-1); GM, gray matter; WM, white matter; n/a, not applicable. aCalculated by the K 1, k 2, and k 3 parameters reported in the paper.