Cerebral blood flow and glucose metabolism in healthy volunteers measured using a high-resolution PET scanner

Huisman, Marc C; van Golen, Larissa W; Hoetjes, Nikie J; Greuter, Henri N; Schober, Patrick; Ijzerman, Richard G; Diamant, Michaela; Lammertsma, Adriaan A

doi:10.1186/2191-219X-2-63

EJNMMI Research

Table 1 Regional CMR _glu , K ₁ , CBF, V _T , and E values obtained in healthy males

From: Cerebral blood flow and glucose metabolism in healthy volunteers measured using a high-resolution PET scanner

Region	CMR _glu	K ₁	CBF	V _T	E
Cerebellum	0.24 ± 0.03 (11)	0.075 ± 0.011 (15)	0.36 ± 0.07 (19)	0.71 ± 0.08 (11)	21 ± 2 (11)
Orbitofrontal cortex	0.34 ± 0.04 (10)	0.065 ± 0.010 (15)	0.42 ± 0.07 (17)	0.69 ± 0.05 (7)	16 ± 2 (14)
Medial inferior frontal cortex	0.39 ± 0.03 (8)	0.073 ± 0.012 (16)	0.42 ± 0.06 (13)	0.71 ± 0.05 (7)	17 ± 3 (15)
Cingulate anterior	0.30 ± 0.04 (12)	0.065 ± 0.009 (14)	0.37 ± 0.05 (13)	0.69 ± 0.05 (8)	17 ± 3 (16)
Thalamus	0.36 ± 0.04 (11)	0.082 ± 0.018 (22)	0.46 ± 0.06 (13)	0.74 ± 0.05 (7)	19 ± 3 (16)
Insula	0.33 ± 0.03 (10)	0.069 ± 0.007 (11)	0.45 ± 0.07 (15)	0.76 ± 0.05 (7)	16 ± 2 (10)
Caudate nucleus	0.38 ± 0.04 (11)	0.067 ± 0.011 (16)	0.39 ± 0.06 (16)	0.68 ± 0.07 (10)	18 ± 3 (17)
Putamen	0.41 ± 0.04 (10)	0.076 ± 0.013 (17)	0.47 ± 0.08 (16)	0.75 ± 0.07 (9)	17 ± 4 (21)
Superior temporal cortex	0.33 ± 0.03 (8)	0.064 ± 0.008 (13)	0.38 ± 0.04 (11)	0.70 ± 0.05 (7)	17 ± 2 (10)
Parietal cortex	0.37 ± 0.02 (6)	0.072 ± 0.009 (12)	0.39 ± 0.05 (12)	0.71 ± 0.05 (7)	19 ± 2 (11)
Medial inferior temporal cortex	0.31 ± 0.03 (11)	0.059 ± 0.007 (13)	0.33 ± 0.05 (15)	0.65 ± 0.06 (10)	18 ± 2 (11)
Superior frontal cortex	0.36 ± 0.03 (8)	0.069 ± 0.009 (13)	0.40 ± 0.06 (14)	0.71 ± 0.05 (7)	17 ± 2 (12)
Occipital cortex	0.35 ± 0.03 (7)	0.067 ± 0.007 (10)	0.38 ± 0.05 (14)	0.68 ± 0.07 (10)	18 ± 1 (8)
Sensorimotor cortex	0.34 ± 0.02 (6)	0.068 ± 0.009 (13)	0.37 ± 0.04 (12)	0.68 ± 0.05 (7)	19 ± 2 (12)
Cingulate posterior	0.41 ± 0.03 (8)	0.079 ± 0.013 (16)	0.44 ± 0.06 (13)	0.73 ± 0.05 (7)	19 ± 2 (12)
Enthorinale	0.19 ± 0.08 (44)	0.047 ± 0.014 (30)	0.26 ± 0.05 (18)	0.59 ± 0.08 (14)	18 ± 4 (25)
Hippocampus	0.22 ± 0.04 (16)	0.057 ± 0.011 (19)	0.30 ± 0.04 (14)	0.67 ± 0.07 (10)	19 ± 4 (20)
White matter	0.19 ± 0.01 (7)	0.046 ± 0.004 (9)	0.25 ± 0.04 (15)	0.61 ± 0.05 (9)	19 ± 2 (10)
Total gray matter	0.29 ± 0.03 (8)	0.062 ± 0.006 (10)	0.35 ± 0.05 (14)	0.64 ± 0.05 (8)	18 ± 1 (8)

Mean ± SD (CoV); data are obtained by NLR analysis based on BSIFs. CMR_glu, cerebral metabolic rate of glucose consumption (in μmol/cm³ per minute (n = 9)); K ₁, rate constant from blood to tissue (in min^-1 (n = 9)); CBF, cerebral blood flow (in mL/cm³ per minute (n = 11)); V _T, volume of distribution (unitless, obtained by CBF measurements (n = 11)); E, FDG extraction fraction (in % (n = 8)).

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