Figure 7
In vivo and in vitro imaging correlations. (a) Correlation between in vivo ([18F]-PBR111 V t and r50′) and in vitro ([125I]-CLINDE autoradiography) measurements of TSPO binding for the hippocampus, thalamus and amygdala. (b) Correlation between [18F]-PBR111 V t and r50′(SC) in vivo measurements of TSPO binding for the hippocampus, thalamus and amygdala. Circles indicate the V t [18F]-PBR111-negative animal, with, in (a), open circles showing the V t values for this animals and closed circles showing the r50′(SC) value of this animal. This animal was excluded for statistical correlation between V t and ARG, and between V t and r50′(SC). ARG, autoradiography. Asterisk indicates P < 0.05; double asterisk, P < 0.01; triple asterisk, P < 0.001; and section sign, P < 0.1.