Figure 4
Time activity curves (TACs) of [18 F ]- PBR111. TACs were expressed as the percentage injected dose per milliliter (%ID/ml) of plasma and several brain regions in the representative control (a) and KASE (severe SE) (b) rats. The increase in the amplitude of the cerebellum is proportional to the plasma in both animals, while the increase in amygdala is much higher in the KASE compared to the control rat. Note that the kinetics of the radioligand is also slower in the amygdala of the KASE animal.