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Table 3 Population parameter estimates and relative standard errors (%) of the ( R )-[ 11 C]verapamil plasma model using mixed effects modeling of the WB region of interest of rats and humans

From: Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood–brain barriers studied with (R)-[11C]verapamil positron emission tomography

Pharmacokinetic parameters Rat Human estimates
Estimates Inter-animal variability
V c (ml) 38.8 0.162 2580
(7.27) (52.3) (−)
V p1 (ml) 141 0.169 57900
(17.6) (23.3) (−)
V p2 (ml) 1580 - 41100
(17.6) (−)
CL (ml·min−1) 16.4 0.162 538
(10.3) (52.3) (−)
Q 1 (ml·min−1) 29.1 0.169 6550
(7.77) (23.3) (−)
Q 2 (ml·min−1) 22.3 0.162 5880
(10.0) (52.3) (−)
Residual error plasma 0.482 - 0.654
  (6.93)   (−)
  1. For definition of parameters, please refer to the legend of Figure 2. The RSA are given in parentheses after the estimates.