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Table 3 Population parameter estimates and relative standard errors (%) of the ( R )-[ 11 C]verapamil plasma model using mixed effects modeling of the WB region of interest of rats and humans

From: Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood–brain barriers studied with (R)-[11C]verapamil positron emission tomography

Pharmacokinetic parameters

Rat

Human estimates

Estimates

Inter-animal variability

V c (ml)

38.8

0.162

2580

(7.27)

(52.3)

(−)

V p1 (ml)

141

0.169

57900

(17.6)

(23.3)

(−)

V p2 (ml)

1580

-

41100

(17.6)

(−)

CL (ml·min−1)

16.4

0.162

538

(10.3)

(52.3)

(−)

Q 1 (ml·min−1)

29.1

0.169

6550

(7.77)

(23.3)

(−)

Q 2 (ml·min−1)

22.3

0.162

5880

(10.0)

(52.3)

(−)

Residual error plasma

0.482

-

0.654

 

(6.93)

 

(−)

  1. For definition of parameters, please refer to the legend of Figure 2. The RSA are given in parentheses after the estimates.