Pharmacokinetic parameters | Rat | Human estimates | |
---|---|---|---|
Estimates | Inter-animal variability | ||
V c (ml) | 38.8 | 0.162 | 2580 |
(7.27) | (52.3) | (−) | |
V p1 (ml) | 141 | 0.169 | 57900 |
(17.6) | (23.3) | (−) | |
V p2 (ml) | 1580 | - | 41100 |
(17.6) | (−) | ||
CL (ml·min−1) | 16.4 | 0.162 | 538 |
(10.3) | (52.3) | (−) | |
Q 1 (ml·min−1) | 29.1 | 0.169 | 6550 |
(7.77) | (23.3) | (−) | |
Q 2 (ml·min−1) | 22.3 | 0.162 | 5880 |
(10.0) | (52.3) | (−) | |
Residual error plasma | 0.482 | - | 0.654 |
(6.93) | (−) |