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Table 2 Number of human volunteers ( n ), weight at time of PET, injected doses (average ± standard deviation) of ( R )-[ 11 C]verapamil for baseline, and post-inhibition scans after tariquidar (2 mg/kg) treatment

From: Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood–brain barriers studied with (R)-[11C]verapamil positron emission tomography

  Healthy volunteers and 2 mg/kg tariquidar treated
Number 5
Body weight (kg) 74±5
Baseline (R)-[11C]verapamil (MBq) 379±11
I.V. injection time (sec) 51±10
Post-inhibition (R)-[11C]verapamil (MBq) 389±15
I.V. injection time (sec) 43±11