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Table 1 Number of animals ( n ), weight at time of PET, injected doses (average ± standard deviation) of ( R )-[ 11 C]verapamil for baseline and post-inhibition scans in naïve and 48-h post SE rats and different treatments with 3 or 15 mg/kg of tariquidar

From: Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood–brain barriers studied with (R)-[11C]verapamil positron emission tomography

  Naïve and 3 mg/kg tariquidar treated Naïve and 15 mg/kg tariquidar treated 48-h post SE and 3 mg/kg tariquidar treated 48-h post SE and 15 mg/kg tariquidar treated All groups
N 7 4 5 5 21
Body weight (g) 260 ± 5 307 ± 18 234 ± 14 247 ± 16 260 ± 28
Baseline (R)-[11C]verapamil (MBq) 97 ± 27 88 ± 17 84 ± 20 94 ± 25 91 ± 22
I.V. injection time (sec) 18 ± 7 39 ± 10 19 ± 2 25 ± 11 24 ± 11
Post-inhibition (R)-[11C]verapamil (MBq) 93 ± 27 101 ± 28 91 ± 9 92 ± 16 94 ± 21
I.V. injection time (sec) 18 ± 6 36 ± 5 16 ± 2 32 ± 18 24 ± 13