Table 1 Number of animals ( n ), weight at time of PET, injected doses (average ± standard deviation) of ( R )-[ 11 C]verapamil for baseline and post-inhibition scans in naïve and 48-h post SE rats and different treatments with 3 or 15 mg/kg of tariquidar
Naïve and 3 mg/kg tariquidar treated | Naïve and 15 mg/kg tariquidar treated | 48-h post SE and 3 mg/kg tariquidar treated | 48-h post SE and 15 mg/kg tariquidar treated | All groups | |
|---|---|---|---|---|---|
N | 7 | 4 | 5 | 5 | 21 |
Body weight (g) | 260 ± 5 | 307 ± 18 | 234 ± 14 | 247 ± 16 | 260 ± 28 |
Baseline (R)-[11C]verapamil (MBq) | 97 ± 27 | 88 ± 17 | 84 ± 20 | 94 ± 25 | 91 ± 22 |
I.V. injection time (sec) | 18 ± 7 | 39 ± 10 | 19 ± 2 | 25 ± 11 | 24 ± 11 |
Post-inhibition (R)-[11C]verapamil (MBq) | 93 ± 27 | 101 ± 28 | 91 ± 9 | 92 ± 16 | 94 ± 21 |
I.V. injection time (sec) | 18 ± 6 | 36 ± 5 | 16 ± 2 | 32 ± 18 | 24 ± 13 |