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Figure 7 | EJNMMI Research

Figure 7

From: Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood–brain barriers studied with (R)-[11C]verapamil positron emission tomography

Figure 7

Modeling results of ( R) -[11 C]verapamil concentration-time curves in WB gray matter in ln(Bq/ml) over time (min). (A) WB gray matter was compared with (B) WB* gray matter excluding the increase of (R)-[11C]verapamil brain uptake after treatment with tariquidar. Tariquidar (2 mg/kg) was administered at 40 min after start of tracer injection as an intravenous infusion over 30 min and post-inhibition scan was started 2 h 50 min after end of tariquidar infusion. Each panel represents one volunteer, open gray circles represent measurements (DV), solid red lines represent the model predictions for each individual subject (IPRE), and broken blue lines represent the population model predictions (PRED).

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