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EJNMMI Research
Figure 6 | EJNMMI Research

Figure 6

From: Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood–brain barriers studied with (R)-[11C]verapamil positron emission tomography

Figure 6

Modeling results of ( R )-[11 C]verapamil concentration-time curves in WB of rats in ln(Bq/ml) over time (min). (A) WB was compared with (B) WB* excluding the increase of (R)-[11C]verapamil brain uptake after treatment with tariquidar from 60 to 140 min. Tariquidar (3 or 15 mg/kg) was administered at 60 min after start of tracer injection as an I.V. bolus over 60 sec and the post-inhibition scan was started 2 h after tariquidar administration. Each panel represents one animal (not all 21 are shown), open gray circles represent measurements (DV), solid red lines represent the model predictions for individual rats (IPRE), and broken blue lines represent the population model predictions (PRED).

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