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EJNMMI Research
Figure 3 | EJNMMI Research

Figure 3

From: Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood–brain barriers studied with (R)-[11C]verapamil positron emission tomography

Figure 3

WB ( R )-[11 C]verapamil time-activity curves in rats. Average ± standard deviation (R)-[11C]verapamil concentration-time curves in rat WB expressed as SUV for naïve (squares) and 48-h post SE (circles) animals at baseline (open symbols) and at post-inhibition (full symbols). Tariquidar (3 mg/kg) was administered 60 min after the start of the baseline scan as an I.V. bolus over 60 sec (arrow).

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