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Figure 1 | EJNMMI Research

Figure 1

From: Blood–brain barrier P-glycoprotein function in healthy subjects and Alzheimer's disease patients: effect of polymorphisms in the ABCB1 gene

Figure 1

Binding potential (BP ND ) of ( R )-[11 C]verapamil. Global BPND in healthy controls (HC, squares) and Alzheimer's disease patients (AD, triangles) as a function of T dose in (A) C1236T, (B) G2677T and (C) C3435T is shown. Mean BPND values and SD are given. (A) C1236T: In HC, BPND values for 0 T, 1 T and 2 T were 1.76 ± 0.45, 1.77 ± 0.45 and 1.79 ± 0.44, and in AD, the values were 1.74 ± 0.33, 2.11 ± 0.37 and 2.22 ± 0.13, respectively. (B) G2677T: In HC, BPND values for 0 T, 1 T and 2 T were 1.76 ± 0.45, 1.76 ± 0.44 and 1.81 ± 0.44, and in AD, the values were 1.74 ± 0.33, 2.11 ± 0.37 and 2.22 ± 0.13, respectively. (C) C3435T: In HC, BPND values for 0 T, 1 T and 2 T were 1.73 ± 0.49, 1.73 ± 0.44 and 1.88 ± 0.39, and in AD, the values were 1.56 ± 0.15, 2.17 ± 0.30 and 2.13 ± 0.27, respectively.

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