Skip to main content

Advertisement

Table 1 Affinities (nM) of IV-OH and reference compounds for sigma receptors

From: Development and evaluation of a novel radioiodinated vesamicol analog as a sigma receptor imaging agent

  Sigma-1 (K i) Sigma-2 (K i)
(+)-IV-OH 22.8 (6.3) 146.9 (13.1)
(−)-IV-OH 45.5 (9.8) 165.5 (69.2)
(+)-Ves-OH 178.6 (25.2) 97.2 (3.1)
(+)-Vesamicol 19.1 (1.8) 159.3 (43.9)
Haloperidol 6.4 (0.7) 63.0 (7.2)
Pentazocine 10.0 (1.1) 2,417.7 (326.2)
  1. K i values derived from IC50 values according to the equation: K i = IC50/(1 + C/K d), where C is the concentration of the radioligand, and each K d is the dissociation constant of the corresponding radioligand ([3H]pentazocine to sigma-1 (K d = 19.9 nM) and [3H]DTG to sigma-2 (K d = 22.3 nM)). Values are means (SEM) of three or four experiments.