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Figure 3 | EJNMMI Research

Figure 3

From: Pretargeted immuno-PET of CEA-expressing intraperitoneal human colonic tumor xenografts: a new sensitive detection method

Figure 3

Images. 3D-volume rendering of the pretargeted immuno-PET scan (a) and the FDG-PET/CT scan (b) of the BALB/c nude mice with intraperitoneal LS174T tumors that received 6.0 nmol TF2 and 5 MBq 68Ga-IMP288 (0.25 nmol) with a 16-h interval (a) or 18F-FDG (b). The animals were imaged 1 h after 68Ga-IMP288 or 18F-FDG injection. Digital pictures were made during dissection to localize and measure individual tumors. On the pretargeted immuno-PET/CT images (a), all dissected tumors were very clearly distinguishable, except for the two very small tumors (1.2 and 4.7 μL, respectively). In the FDG-PET/CT images (b), arrows are pointed at the localizations where tumors were found at dissection, but the signal was difficult to be discriminated from the intestines. Figure 3c, d shows the PET/CT images of mice without intraperitoneal images after TF2 and 68Ga-IMP288 injection (c) or 18F-FDG injection (d).

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