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EJNMMI Research
Figure 5 | EJNMMI Research

Figure 5

From: Single-photon emission computed tomography of spontaneous liver metastasis from orthotopically implanted human colon cancer cell line stably expressing human sodium/iodide symporter reporter gene

Figure 5

Immunohistochemistry. Demonstrating NIS in the liver tumor tissue of representative mice implanted with a line B tumor fragment (A and C) and a line N negative control fragment (B and D). Areas bordered by dotted lines indicate the liver tumors. High levels of NIS expression were observed in cells (black arrows) forming the liver tumor except for intratumoral necrotic regions (red arrow) of the mice with line B tumor fragments, but no NIS expression was observed in the tumor cells (white arrows) in the liver of mice implanted with line N fragments.

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