Lateral radiographs of the infected tibias. In animals with S. aureus (52/52A/80) (a), S. epidermidis (ATCC 35983) (b), or S. epidermidis (T-54580) inoculum (c) at 8 weeks. The S. aureus group of animals (a) showed more prominent periosteal reaction, architectural distortion of the metaphyseal cancellous bone, widening of the tibial shaft, and a completely open cortical window (large arrow). The block of bone cement was visible on the radiographs of the S. epidermidis groups of animals (b and c, small arrow). The animals with S. epidermidis (ATCC 35983) inoculum (b) showed partial healing of the cortical defect (large arrow) and minimal changes of the local bone architecture. In animals with S. epidermidis (T-54580) inoculum (c), the cortical window was open and accompanied with periosteal reaction and minor distortion of the surrounding bone architecture.