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Table 3 Percentage of  V ND in total distribution volume in rhesus monkeys

From: Synthesis and evaluation of 2-chloro N-[(S)-{(S)-1-[11 C]methylpiperidin-2-yl} (phenyl)methyl]3-trifluoromethyl-benzamide ([11 C]N-methyl-SSR504734) as a PET radioligand for glycine transporter 1

Study Parameter Pons CB CAU PUT FC ACC TC
Baseline + blocking (1.5 mg/kg) V T 31 35.2 23.7 26.2 26.7 25.2 28.6
  V ND 16.5 16.5 16.5 16.5 16.5 16.5 16.5
  % of V ND in V T 66 50 55 55 52 59 54
Baseline + blocking (4.5 mg/kg) V T 16.9 12.8 17 15.8 14.3 15.5 12.3
  V ND 7.5 7.5 7.5 7.5 7.5 7.5 7.5
  % of V ND in V T 56 42 56 53 48 52 39
  1. ACC, anterior cingulate cortex; CAU, caudate; CB, cerebellum; FC, frontal cortex; PUT, putamen; TC, temporal cortex; V ND, nondisplaceable distribution; V T, volume distribution volume.