Synthesis and evaluation of 2-chloro N-[(S)-{(S)-1-[11 C]methylpiperidin-2-yl} (phenyl)methyl]3-trifluoromethyl-benzamide ([11 C]N-methyl-SSR504734) as a PET radioligand for glycine transporter 1

EJNMMI Research

Table 3 Percentage of V _ND in total distribution volume in rhesus monkeys

Study	Parameter	Pons	CB	CAU	PUT	FC	ACC	TC
Baseline + blocking (1.5 mg/kg)	V _T	31	35.2	23.7	26.2	26.7	25.2	28.6
	V _ND	16.5	16.5	16.5	16.5	16.5	16.5	16.5
	% of V _ND in V _T	66	50	55	55	52	59	54
Baseline + blocking (4.5 mg/kg)	V _T	16.9	12.8	17	15.8	14.3	15.5	12.3
	V _ND	7.5	7.5	7.5	7.5	7.5	7.5	7.5
	% of V _ND in V _T	56	42	56	53	48	52	39

ACC, anterior cingulate cortex; CAU, caudate; CB, cerebellum; FC, frontal cortex; PUT, putamen; TC, temporal cortex; V _ND, nondisplaceable distribution; V _T, volume distribution volume.