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Table 1 Synthetic condition for preparation of [1111C] N -methyl-SSR504734

From: Synthesis and evaluation of 2-chloro N-[(S)-{(S)-1-[11 C]methylpiperidin-2-yl} (phenyl)methyl]3-trifluoromethyl-benzamide ([11 C]N-methyl-SSR504734) as a PET radioligand for glycine transporter 1

Entry [11 C] methylating agent Base Solvent Temperature Time (min) Yield (%)
1 [11 C]CH3I NaH DMF r.t. 5 0
2 [11 C]CH3I NaOH DMF r.t. 5 0
3 [11 C]CH3I NaOH DMF 80 °C 5 0
4 [11 C]CH3OTf NaOH Acetone r.t. 1 25
5 [11 C]CH3OTf NaOH CH3CN r.t. 1 36 to approximately 42
  1. DMF, dimethylformamide; r.t., room temperature.