Table 1 Synthetic condition for preparation of [1111C] N -methyl-SSR504734
Entry | [11 C] methylating agent | Base | Solvent | Temperature | Time (min) | Yield (%) |
|---|---|---|---|---|---|---|
1 | [11 C]CH3I | NaH | DMF | r.t. | 5 | 0 |
2 | [11 C]CH3I | NaOH | DMF | r.t. | 5 | 0 |
3 | [11 C]CH3I | NaOH | DMF | 80 °C | 5 | 0 |
4 | [11 C]CH3OTf | NaOH | Acetone | r.t. | 1 | 25 |
5 | [11 C]CH3OTf | NaOH | CH3CN | r.t. | 1 | 36 to approximately 42 |