Time-activity curves of brain radioactivity after intravenous injection of [11 C] N -methyl-SSR504734 in a cynomolgus monkey. At baseline and pretreatment conditions (0.5 or 1.5 mg/kg of SSR504734). Whole brain uptake was expressed as percent injected dose (%ID) (A). Regional brain uptake was expressed as percent standard uptake value (%SUV) under baseline (B), pretreatment of SSR504734 (0.5 mg/kg) (C), and pretreatment of SSR504734 (1.5 mg/kg) conditions (D). Black square, thalamus; white circle, pons; black triangle, cerebellum; white diamond, putamen; asterisk, frontal cortex; cross, white matter; black circle, caudate; white square, anterior cingulate cortex; white triangle, temporal cortex.