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Table 4 Percentage of intact [11 C]phenytoin at different time points after injection ( N= 2)

From: [11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats

Time (min) Plasma (%) Brain (%)
5 60 ± 7  
10 50 ± 16  
15 38 ± 3  
25 28 ± 2 95 ± 1
30 32 ± 18  
45 19 ± 8 83 ± 5
  1. Although moderate [11C]phenytoin metabolism in the periphery may be acceptable, it requires metabolite correction of plasma input functions for quantification of tracer kinetics, especially since it will be difficult to define a proper reference region.