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EJNMMI Research

Table 4 Percentage of intact [11 C]phenytoin at different time points after injection ( N = 2)

From: [11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats

Time (min)

Plasma (%)

Brain (%)

5

60 ± 7

 

10

50 ± 16

 

15

38 ± 3

 

25

28 ± 2

95 ± 1

30

32 ± 18

 

45

19 ± 8

83 ± 5

  1. Although moderate [11C]phenytoin metabolism in the periphery may be acceptable, it requires metabolite correction of plasma input functions for quantification of tracer kinetics, especially since it will be difficult to define a proper reference region.
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