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Table 2 Affected biological processes (GO terms) categorized after function

From: Transcriptional response of BALB/c mouse thyroids following in vivo astatine-211 exposure reveals distinct gene expression profiles

Biological process Absorbed dose (Gy)
0.05 0.5 1.4 11 32
Cellular process 4 1 1 2 2
 Collagen fibril organization     
 Cytolysis     
 Epithelial cell differentiation     
 Mitochondrion organization and biogenesis     
 Negative regulation of endothelial cell proliferation      
 Cytoskeleton organization and biogenesis   
 Cell migration      
 Negative regulation of microtubule depolymerization     
Immune response 2 0 0 1 0
 Positive regulation of immune response     
 Positive thymic T cell selection     
 B cell proliferation      
Metabolic process 7 13 7 5 4
 Protein amino acid glycosylation     
 Regulation of metabolism     
 Lipid metabolism    
 Metabolism    
 Regulation of peptidyl-tyrosine phosphorylation    
 Tricarboxylic acid cycle    
 Ubiquinone biosynthesis    
 Cellular protein metabolism      
 Cholesterol biosynthesis      
 Electron transport      
 Fatty acid metabolism      
 Glycolysis      
 Hormone metabolism      
 Protein folding      
 Acetyl-CoA biosynthesis from pyruvate      
 Amino acid biosynthesis      
 Retinoid metabolism      
 Signal peptide processing      
 tRNA processing      
 Peptidoglycan metabolism      
 Thyroid hormone generation     
 One-carbon compound metabolism     
 Cholesterol metabolism      
 Steroid metabolism      
 Phosphocreatine metabolism    
 Lipopolysaccharide biosynthesis    
 Carbohydrate metabolism     
Transport 3 5 6 3 3
 Oxygen transport     
 Secretion    
 Potassium ion transport
 Protein transport      
 Transport     
 Ion transport  
 Glucose transport      
 Iron ion transport      
 Vesicle-mediated transport      
 Diuresis      
 Sodium ion transport     
Response to stimulus 0 1 5 2 0
 Response to unfolded protein      
 Chemotaxis      
 Response to cold      
 Response to hypoxia      
 Small GTPase signal transduction      
 Transmembrane receptor protein tyrosine kinase SP      
 G protein signaling      
 G protein receptor protein signaling pathway      
System process 2 2 2 3 2
 Muscle contraction  
 Regulation of muscle contraction
 Vasoconstriction      
 Digestion      
Developmental process 2 1 4 5 2
 Vasculogenesis     
 Fat cell differentiation    
 Brain development      
 Cellular morphogenesis during differentiation      
 Regulation of bone mineralization      
 Cartilage condensation     
 Bone mineralization      
 Brown fat cell differentiation      
 Male gonad development      
 Mechanoreceptor differentiation    
 Muscle development     
  1. Transcripts with different gene expression levels are connected to biological processes (p < 0.05) through Gene Ontology terms. The main terms (cellular process, immune response, metabolic process, transport, response to stimulus, system process, and developmental process) have been compiled using the Gene Ontology search function [21, 22]. Numbers presented after the main terms represent the number of affected biological processes for each absorbed-dose profile.