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Table 2 Affected biological processes (GO terms) categorized after function

From: Transcriptional response of BALB/c mouse thyroids following in vivo astatine-211 exposure reveals distinct gene expression profiles

Biological process

Absorbed dose (Gy)

0.05

0.5

1.4

11

32

Cellular process

4

1

1

2

2

 Collagen fibril organization

✓

    

 Cytolysis

✓

    

 Epithelial cell differentiation

✓

    

 Mitochondrion organization and biogenesis

✓

    

 Negative regulation of endothelial cell proliferation

 

✓

   

 Cytoskeleton organization and biogenesis

  

✓

✓

✓

 Cell migration

   

✓

 

 Negative regulation of microtubule depolymerization

    

✓

Immune response

2

0

0

1

0

 Positive regulation of immune response

✓

    

 Positive thymic T cell selection

✓

    

 B cell proliferation

   

✓

 

Metabolic process

7

13

7

5

4

 Protein amino acid glycosylation

✓

    

 Regulation of metabolism

✓

    

 Lipid metabolism

✓

✓

   

 Metabolism

✓

✓

   

 Regulation of peptidyl-tyrosine phosphorylation

✓

✓

   

 Tricarboxylic acid cycle

✓

✓

   

 Ubiquinone biosynthesis

✓

✓

   

 Cellular protein metabolism

 

✓

   

 Cholesterol biosynthesis

 

✓

   

 Electron transport

 

✓

   

 Fatty acid metabolism

 

✓

   

 Glycolysis

 

✓

   

 Hormone metabolism

 

✓

   

 Protein folding

 

✓

   

 Acetyl-CoA biosynthesis from pyruvate

 

✓

   

 Amino acid biosynthesis

  

✓

  

 Retinoid metabolism

  

✓

  

 Signal peptide processing

  

✓

  

 tRNA processing

  

✓

  

 Peptidoglycan metabolism

  

✓

  

 Thyroid hormone generation

  

✓

✓

 

 One-carbon compound metabolism

  

✓

 

✓

 Cholesterol metabolism

   

✓

 

 Steroid metabolism

   

✓

 

 Phosphocreatine metabolism

   

✓

✓

 Lipopolysaccharide biosynthesis

   

✓

✓

 Carbohydrate metabolism

    

✓

Transport

3

5

6

3

3

 Oxygen transport

✓

    

 Secretion

✓

✓

   

 Potassium ion transport

✓

✓

✓

✓

✓

 Protein transport

 

✓

   

 Transport

 

✓

✓

  

 Ion transport

 

✓

✓

✓

✓

 Glucose transport

  

✓

  

 Iron ion transport

  

✓

  

 Vesicle-mediated transport

  

✓

  

 Diuresis

   

✓

 

 Sodium ion transport

    

✓

Response to stimulus

0

1

5

2

0

 Response to unfolded protein

 

✓

   

 Chemotaxis

  

✓

  

 Response to cold

  

✓

  

 Response to hypoxia

  

✓

  

 Small GTPase signal transduction

  

✓

  

 Transmembrane receptor protein tyrosine kinase SP

  

✓

  

 G protein signaling

   

✓

 

 G protein receptor protein signaling pathway

   

✓

 

System process

2

2

2

3

2

 Muscle contraction

✓

✓

 

✓

✓

 Regulation of muscle contraction

✓

✓

✓

✓

✓

 Vasoconstriction

  

✓

  

 Digestion

   

✓

 

Developmental process

2

1

4

5

2

 Vasculogenesis

✓

    

 Fat cell differentiation

✓

✓

   

 Brain development

  

✓

  

 Cellular morphogenesis during differentiation

  

✓

  

 Regulation of bone mineralization

  

✓

  

 Cartilage condensation

  

✓

✓

 

 Bone mineralization

   

✓

 

 Brown fat cell differentiation

   

✓

 

 Male gonad development

   

✓

 

 Mechanoreceptor differentiation

   

✓

✓

 Muscle development

    

✓

  1. Transcripts with different gene expression levels are connected to biological processes (p < 0.05) through Gene Ontology terms. The main terms (cellular process, immune response, metabolic process, transport, response to stimulus, system process, and developmental process) have been compiled using the Gene Ontology search function [21, 22]. Numbers presented after the main terms represent the number of affected biological processes for each absorbed-dose profile.