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Table 3 Overview of studies comparing cerebrovascular reactivity with CBF or OEF

From: Comparison of oxygen-15 PET and transcranial Doppler CO2-reactivity measurements in identifying haemodynamic compromise in patients with symptomatic occlusion of the internal carotid artery

Author Method 1 Method 2 Sample (n) ICA occlusion Symptoms Agreement between methods
Fujimoto et al. 2002 [29] IMP-SPECT + ACZ 15O-PET 53 18 47 Haemodynamic compromise in 75% by method 1, 32% by method 2 (increased OEF, stage 2), and 64% by method 2 (stage 1).
Correlation CVR (asymmetry index) with CBF/CBV r = 0.31 (p < 0.05)
Correlation CVR with OEF r = −0.64 (p < 0.0001)
Herold et al. 1988 [25] Xenon-SPECT + CO2 15O-PET 21 19 7 Haemodynamic compromise in 29% by method 1 and 19% by method 2 (increased OEF)
Correlation CVR with CBF/CBV r = 0.575 (p < 0.01)
Correlation CVR with oxygen extraction ratio r = −0.573 (p < 0.01)
Imaizumi et al. 2002 [28] IMP-SPECT + ACZ 15O-PET 27 9 22 No data on the number of patients with haemodynamic compromise
Correlation CVR with CBV r = −0.31 (p < 0.01)
Correlation CVR with OEF r = −0.55 (p < 0.0001)
Nariai et al. 1995 [26] Xenon CT + ACZ 15O-PET 11 4 10 No data on number of patients with haemodynamic compromise
Correlation CVR with CBV r = −0.50 (p = 0.02)
Correlation CVR with OEF r = −0.65 (p = 0.001)
Nemoto et al. 2004 [27] Xenon CT + ACZ 15O-PET 12 12 12 Haemodynamic compromise in 50% by method 1 and 17% by method 2 (increased OEF)
Correlation CVR with OEF r = −0.57 (p = 0.001)
Sugimori et al. 1995 [24] TCD + CO2 15O-PET 22 2 7 Haemodynamic compromise in 52% by method 1 and 9% by method 2 (increased OEF)
Correlation CVR with CBF r = 0.47 (p < 0.05)
Correlation CVR with OEF r = 0.20 (ns)
  1. TCD, transcranial Doppler; CO2, carbon dioxide; ACZ, acetazolamide; CT, computed tomography; PET, positron emission tomography; CVR, cerebrovascular reactivity; CBF, cerebral blood flow; OEF, oxygen extraction fraction; CBV, cerebral blood volume.