[18F]CFT synthesis and binding to monoamine transporters in rats

EJNMMI Research

Table 3 ¹⁸F-activity uptake after injection of [¹⁸F]CFT in the organs of control and pretreated rats

Organ	10 min n= 2	20 min n= 3	40 min n= 4	120 min n= 3	GBR12909 n= 3	Nisoxetine n= 3	Fluoxetine n= 2
Blood	0.06 ± 0.03	0.07 ± 0.01	0.05 ± 0.02	0.03 ± 0.01	0.04 ± 0.01	0.06 ± 0.01	0.03 ± 0.02
Liver	0.65 ± 0.45	5.17 ± 1.99	4.90 ± 3.74	8.26 ± 1.16	3.38 ± 0.94	5.86 ± 0.10	4.22 ± 1.22
Adrenal gland	0.28 ± 0.14	0.36 ± 0.01	0.24 ± 0.03	0.17 ± 0.06	0.23 ± 0.07	0.25 ± 0.02	0.24 ± 0.11
Spleen	0.36 ± 0.24	0.88 ± 0.28	0.49 ± 0.05	0.26 ± 0.13	0.50 ± 0.19	0.44 ± 0.07	0.44 ± 0.02
Pancreas	0.28 ± 0.10	0.53 ± 0.04	0.35 ± 0.11	0.16 ± 0.01	0.17 ± 0.05*	0.31 ± 0.02	0.22 ± 0.12
Kidney	0.72 ± 0.16	0.91 ± 0.11	0.66 ± 0.31	0.28 ± 0.07	0.53 ± 0.13	0.47 ± 0.02	0.41 ± 0.18
Stomach	0.12 ± 0.09	0.53 ± 0.38	0.19 ± 0.05	0.08 ± 0.05	0.47 ± 0.37	0.11 ± 0.01	0.17
Lung	0.51 ± 0.37	0.46 ± 0.07	0.29 ± 0.08	0.17 ± 0.06	0.20 ± 0.05	0.25 ± 0.01	0.25 ± 0.04
Heart	0.14 ± 0.06	0.16 ± 0.03	0.11 ± 0.02	0.07 ± 0.02	0.10 ± 0.03	0.11 ± 0.01	0.13 ± 0.02
Muscle	0.07 ± 0.02	0.15 ± 0.03	0.09 ± 0.03	0.05 ± 0.01	0.08 ± 0.02	0.10 ± 0.01	0.07 ± 0.03
Urinary bladder	0.14 ± 0.14	0.51 ± 0.23	0.31 ± 0.13	0.24 ± 0.13	0.30 ± 0.12	0.28 ± 0.01	0.22 ± 0.04
Bone	0.03 ± 0.01	0.09 ± 0.02	0.07 ± 0.04	0.19 ± 0.15	0.06 ± 0.01	0.31 ± 0.20	0.09 ± 0.04
Marrow	0.22 ± 0.16	0.63 ± 0.17	0.47 ± 0.10	0.20 ± 0.05	0.39 ± 0.12	0.49 ± 0.05	0.40 ± 0.04
Fat, subcutaneous	0.03 ± 0.01	0.06 ± 0.01	0.07 ± 0.03	0.03 ± 0.01	0.04 ± 0.02	0.07 ± 0.01	0.05 ± 0.03

*p < 0.05 compared to 40 min. Uptakes (percent injected dose per gram tissue) occurred in the organs of control rats at different time points and in organs of pretreated rats at 40 min. All values are means ± SD. The effect of pretreatment was compared with the uptake values of control rats at 40 min. Means were considered significantly different when p < 0.05.