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Table 1 Binding profiles of the monoamine transporter antagonist used in this study

From: [18F]CFT synthesis and binding to monoamine transporters in rats

Antagonist

DAT

SERT

NET

CFT [37]

22.9 ± 0.4

100 ± 13

38.6 ± 9.9

GBR12909 [38]

10.6 ± 1.9a

132 ± 0b

496 ± 22c

Fluoxetine [39]

3600 ± 100

0.81 ± 0.02

240 ± 10

Nisoxetine [40]

477

383

5.1

  1. aHalf maximum inhibitory concentration [IC50] (nanomolar [nM]) of [3H]CFT;bIC50 (nM) of [3H]citalopram;cIC50 (nM) of [3H]nisoxetine. DAT, dopamine transporter; SERT, serotonin transporter; NET, norepinephrine transporter. Values are Ki (nM) ± SEM, unless otherwise stated.