Antagonist | DAT | SERT | NET |
---|
CFT [37] | 22.9 ± 0.4 | 100 ± 13 | 38.6 ± 9.9 |
GBR12909 [38] | 10.6 ± 1.9a
| 132 ± 0b
| 496 ± 22c
|
Fluoxetine [39] | 3600 ± 100 | 0.81 ± 0.02 | 240 ± 10 |
Nisoxetine [40] | 477 | 383 | 5.1 |
-
aHalf maximum inhibitory concentration [IC50] (nanomolar [nM]) of [3H]CFT;bIC50 (nM) of [3H]citalopram;cIC50 (nM) of [3H]nisoxetine. DAT, dopamine transporter; SERT, serotonin transporter; NET, norepinephrine transporter. Values are Ki (nM) ± SEM, unless otherwise stated.