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Table 1 Binding profiles of the monoamine transporter antagonist used in this study

From: [18F]CFT synthesis and binding to monoamine transporters in rats

Antagonist DAT SERT NET
CFT [37] 22.9 ± 0.4 100 ± 13 38.6 ± 9.9
GBR12909 [38] 10.6 ± 1.9a 132 ± 0b 496 ± 22c
Fluoxetine [39] 3600 ± 100 0.81 ± 0.02 240 ± 10
Nisoxetine [40] 477 383 5.1
  1. aHalf maximum inhibitory concentration [IC50] (nanomolar [nM]) of [3H]CFT;bIC50 (nM) of [3H]citalopram;cIC50 (nM) of [3H]nisoxetine. DAT, dopamine transporter; SERT, serotonin transporter; NET, norepinephrine transporter. Values are Ki (nM) ± SEM, unless otherwise stated.