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Table 3 Cumulative biodistribution data of [ 111 In]AT2S in AR4-2J and HEK293-hsst 2A + , -hsst 3 + , and -hsst 5 + tumor-bearing SCID mice

From: [111In-DOTA]Somatostatin-14 analogs as potential pansomatostatin-like radiotracers - first results of a preclinical study

[111In]AT2S (%ID/g tissue ± SD)

Organs

AR4-2J

HEK293-hsst 2A +

HEK293-hsst 3 +

HEK293-hsst 5 +

 

1 h

4 h

4 h + Tate a

4 h

4 h + DP2 b

4 h

4 h + AT2S c

4 h

4 h + AT2S c

Blood

1.34 ± 0.21

0.19 ± 0.02

0.26 ± 0.03

0.23 ± 0.07

0.66 ± 0.35

0.19 ± 0.03

0.2 ± 0.10

0.1 ± 0.04

0.23 ± 0.03

Liver

1.27 ± 0.09

0.95 ± 0.21

1.02 ± 0.11

1.31 ± 0.36

0.963 ± 0.67

1.02 ± 0.19

1.09 ± 0.2

1.1 ± 0.08

1.25 ± 0.09

Heart

0.67 ± 0.12

0.18 ± 0.05

0.17 ± 0.04

0.22 ± 0.05

0.38 ± 0.10

0.15 ± 0.04

0.15 ± 0.01

0.15 ± 0.02

0.18 ± 0.03

Kidneys

23.83 ± 4.28

21.10 ± 4.43

24.41 ± 9.15

23.20 ± 7.04

25.51 ± 3.70

23.42 ± 4.69

23.55 ± 8.96

24.12 ± 1.21

24.68 ± 2.20

Stomach

3.23 ± 0.77

1.81 ± 0.47

0.18 ± 0.07***

1.96 ± 0.53

1.29 ± 0.36

3.41 ± 0.97

0.19 ± 0.05***

3.06 ± 0.73

0.17 ± 0.2***

Intestines

1.98 ± 0.29

1.92 ± 0.25

0.77 ± 0.58*

2.00 ± 0.48

1.74 ± 1.02

2.39 ± 0.43

0.54 ± 0.2***

1.54 ± 0.09

0.57 ± 0.20***

Spleen

0.84 ± 0.21

1.10 ± 0.63

0.61 ± 0.18

0.46 ± 0.11

0.50 ± 0.36

0.82 ± 0.11

0.98 ± 0.23

0.78 ± 0.07

1.08 ± 0.16

Muscle

0.22 ± 0.02

0.06 ± 0.01

0.07 ± 0.01

0.07 ± 0.02

0.07 ± 0.03

0.06 ± 0.01

0.07 ± 0.02

0.06 ± 0.01

0.06 ± 0.02

Lung

2.05 ± 0.52

1.43 ± 1.36

3.30 ± 4.93

1.37 ± 0.55

0.47 ± 0.08

0.68 ± 0.29

0.73 ± 0.14

0.56 ± 0.28

0.83 ± 0.13

Femur

0.49 ± 0.12

0.40 ± 0.24

0.19 ± 0.02

0.24 ± 0.09

0.21 ± 0.11

0.23 ± 0.03

0.23 ± 0.04

-

-

Pancreas

7.35 ± 0.74

5.13 ± 0.75

0.15 ± 0.05**

5.73 ± 1.28

0.16 ± 0.10***

3.33 ± 0.4

0.11 ± 0.01***

2.79 ± 0.4

0.43 ± 0.54***

Tumor

3.05 ± 0.51

1.82 ± 0.36

0.21 ± 0.17***

1.49 ± 0.2

0.27 ± 0.20***

1.24 ± 0.27

0.32 ± 0.06***

0.41 ± 0.12

0.22 ± 0.006*

  1. *Significant (p < 0.05), and ** and ***highly significant (p < 0.005) difference between blocked and unblocked animals (Student’s t test). aCo-injection of 50 nmol Tate; bco-injection of 35 nmol DP2; cco-injection of 35 nmol AT2S.