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EJNMMI Research

Table 2 Affinity profile (IC 50 in nanomolar) of AT1S and AT2S for the human sst 1-5 receptors

From: [111In-DOTA]Somatostatin-14 analogs as potential pansomatostatin-like radiotracers - first results of a preclinical study

Code hsst1 hsst2 hsst3 hsst4 hsst5
SS14 1.9 ± 0.5 (5) 0.7 ± 0.2 (5) 3.3 ± 1.7 (4) 1.6 ± 0.8 (4) 4.2 ± 0.7 (3)
SS28 2.7 ± 0.5 (3) 2.5 ± 0.1 (3) 2.2 ± 0.6 (3) 2.1 ± 0.4 (3) 2.0 ± 0.2 (3)
AT1S 5.1 ± 1.4 (3) 2.8 ± 0.3 (3) 1.8 ± 0.6 (3) 2.5 ± 0.6 (3) 17 ± 3 (3)
AT2S 14 ± 2 (3) 1.5 ± 0.3 (3) 2.4 ± 0.5 (3) 3.7 ± 0.7 (3) 12 ± 2 (3)
  1. Mean ± SEM (numbers in parentheses = number of experiments). The profile for the human sst1-5 receptors was determined by receptor autoradiography experiments; [Leu8,DTrp22,125I-Tyr25]SS28 was used as the radioligand and SS14 and SS28 as control compounds.
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