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EJNMMI Research

Table 2 Affinity profile (IC 50 in nanomolar) of AT1S and AT2S for the human sst 1-5 receptors

From: [111In-DOTA]Somatostatin-14 analogs as potential pansomatostatin-like radiotracers - first results of a preclinical study

Code

hsst1

hsst2

hsst3

hsst4

hsst5

SS14

1.9 ± 0.5 (5)

0.7 ± 0.2 (5)

3.3 ± 1.7 (4)

1.6 ± 0.8 (4)

4.2 ± 0.7 (3)

SS28

2.7 ± 0.5 (3)

2.5 ± 0.1 (3)

2.2 ± 0.6 (3)

2.1 ± 0.4 (3)

2.0 ± 0.2 (3)

AT1S

5.1 ± 1.4 (3)

2.8 ± 0.3 (3)

1.8 ± 0.6 (3)

2.5 ± 0.6 (3)

17 ± 3 (3)

AT2S

14 ± 2 (3)

1.5 ± 0.3 (3)

2.4 ± 0.5 (3)

3.7 ± 0.7 (3)

12 ± 2 (3)

  1. Mean ± SEM (numbers in parentheses = number of experiments). The profile for the human sst1-5 receptors was determined by receptor autoradiography experiments; [Leu8,DTrp22,125I-Tyr25]SS28 was used as the radioligand and SS14 and SS28 as control compounds.
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