| |
177Lu-DOTA-PEG
5k-Lys-BN
|
|---|
| |
1 h p.i.
|
24 h p.i.
|
|---|
|
Tissue
|
0.3 nmol
|
3.0 nmol
|
0.3 nmol
|
3.0 nmol
|
|---|
|
Blood
|
0.51 ± 0.09
|
0.77 ± 0.11*
|
0.02 ± 0.00
|
0.02 ± 0.00
|
|
Heart
|
0.22 ± 0.05
|
0.31 ± 0.09
|
0.04 ± 0.01
|
0.05 ± 0.01
|
|
Lung
|
0.92 ± 0.59
|
2.03 ± 1.64
|
0.44 ± 0.32
|
0.58 ± 0.36
|
|
Spleen
|
0.45 ± 0.11
|
0.39 ± 0.05
|
0.40 ± 0.06
|
0.21 ± 0.04
|
|
Kidneys
|
3.11 ± 0.42
|
3.92 ± 0.59
|
1.59 ± 0.42
|
2.12 ± 0.21
|
|
Pancreas
|
4.65 ± 0.18**
|
1.45 ± 0.18
|
3.72 ± 0.98*
|
0.90 ± 0.26
|
|
Stomach
|
0.42 ± 0.09
|
0.89 ± 0.65
|
0.16 ± 0.03
|
0.14 ± 0.10
|
|
Small intestine
|
0.55 ± 0.02
|
0.78 ± 0.39
|
0.20 ± 0.04*
|
0.10 ± 0.02
|
|
Colon
|
0.79 ± 0.14
|
0.59 ± 0.10
|
0.31 ± 0.08*
|
0.11 ± 0.03
|
|
Liver
|
0.50 ± 0.06
|
0.64 ± 0.07
|
0.51 ± 0.05
|
0.46 ± 0.02
|
|
Muscle
|
0.17 ± 0.03
|
0.20 ± 0.05
|
0.02 ± 0.01
|
0.02 ± 0.00
|
|
Bone
|
0.21 ± 0.03
|
0.31 ± 0.03
|
0.23 ± 0.03
|
0.22 ± 0.03
|
|
Tumour
|
2.06 ± 0.41*
|
1.47 ± 0.42
|
1.14 ± 0.10
|
0.66 ± 0.26
|
|
Tumour-to-blood
|
4.08 ± 0.54
|
1.89 ± 0.42
|
62.46 ± 3.58
|
36.24 ± 13.73
|
|
Tumour-to-liver
|
4.11 ± 0.67
|
2.28 ± 0.60
|
2.78 ± 0.21
|
1.47 ± 0.56
|
|
Tumour-to-kidney
|
0.67 ± 0.14
|
0.38 ± 0.13
|
0.62 ± 0.07
|
0.33 ± 0.16
|
|
Tumour-to-muscle
|
12.26 ± 4.01
|
7.20 ± 0.90
|
55.89 ± 32.86
|
27.27 ± 11.92
|
|
Tumour-to-pancreas
|
0.44 ± 0.08
|
1.01 ± 0.23
|
0.28 ± 0.08
|
0.62 ± 0.22
|
- *P < 0.05.; **P < 0.001. Data in percentage of injected dose per gram of tissue (%ID/g), expressed as mean ± SD at 1 and 24 h p.i. (n = 3).
