| |
177Lu-DOTA-Lys-BN
|
177Lu-DOTA-PEG
5k-Lys-BN
|
177Lu-DOTA-Lys-BN
|
177Lu-DOTA-PEG
5k-Lys-BN
|
|---|
|
Tissue
|
1 h p.i.
|
24 h p.i.
|
1 h p.i.
|
24 h p.i.
|
1 h p.i. blocked
|
1 h p.i. blocked
|
|---|
|
Blood
|
0.24 ± 0.07
|
0.00 ± 0.00
|
1.54 ± 0.33*
|
0.01 ± 0.00*
| | |
|
Heart
|
0.14 ± 0.06
|
0.01 ± 0.01
|
0.49 ± 0.05
|
0.04 ± 0.01
| | |
|
Lung
|
0.36 ± 0.08
|
0.02 ± 0.01
|
1.10 ± 0.15
|
0.13 ± 0.02
| | |
|
Spleen
|
0.42 ± 0.12
|
0.18 ± 0.04
|
0.72 ± 0.02
|
0.19 ± 0.03
| | |
|
Kidneys
|
2.86 ± 0.63
|
1.41 ± 0.14
|
4.89 ± 1.33
|
1.84 ± 0.52
| | |
|
Pancreas
|
8.68 ± 1.95
|
4.27 ± 0.85
|
9.62 ± 2.39
|
4.87 ± 1.11
|
0.49 ± 0.22**
|
0.98 ± 0.59*
|
|
Stomach
|
0.72 ± 0.19
|
0.10 ± 0.02
|
1.12 ± 0.15
|
0.22 ± 0.07
| | |
|
Small intestine
|
1.38 ± 0.41
|
0.16 ± 0.03
|
1.18 ± 0.22
|
0.17 ± 0.12
| | |
|
Colon
|
1.64 ± 0.40
|
0.36 ± 0.09
|
2.19 ± 0.91
|
0.45 ± 0.21
|
0.36 ± 0.07**
|
0.66 ± 0.14
|
|
Liver
|
0.26 ± 0.09
|
0.09 ± 0.02
|
0.57 ± 0.04
|
0.16 ± 0.09
| | |
|
Muscle
|
0.20 ± 0.24
|
0.01 ± 0.00
|
0.31 ± 0.06
|
0.42 ± 0.69
| | |
|
Bone
|
0.36 ± 0.24
|
0.02 ± 0.01
|
0.70 ± 0.06
|
0.58 ± 0.44
| | |
|
Tumour
|
1.88 ± 0.47
|
0.54 ± 0.30
|
3.43 ± 0.63*
|
1.04 ± 0.04
|
0.55 ± 0.03*
|
1.02 ± 0.34**
|
- *P < 0.05; **P < 0.01. Data in percentage of injected dose per gram of tissue (%ID/g), expressed as mean ± SD at 1 and 24 h p.i. (n = 3 to 4).
