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EJNMMI Research

Table 1 Analytical and PSMA-binding data

From: A dimerized urea-based inhibitor of the prostate-specific membrane antigen for 68Ga-PET imaging of prostate cancer

Ga-peptide complexes

m/z a

m/z calculated as [M + H] +

AnalyticalHPLC retention (min) b

Affinity-related IC 50determined in enzyme-based assay (nM) c

Affinity-related IC 50determined in cell-based assay (nM) c

[Ga]6

947.4257

947.4250

3.1

9.0 ± 1.1

12.1 ± 2.1

[Ga]7

1,361.6387

1,361.6364

3.1

2.1 ± 1.4

3.8 ± 1.8

  1. aHigh-resolution mass spectrometry data of the free ligands ([M + H]+); bcompounds were labeled with 68Ga; runs were performed using a linear A-B gradient (0% B to 100% B in 6 min) at a flow rate of 4 mL/min; solvent A was 0.1% aqueous TFA, and solvent B was MeOH; ccompounds were complexed with natGa.
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