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Table 1 Analytical and PSMA-binding data

From: A dimerized urea-based inhibitor of the prostate-specific membrane antigen for 68Ga-PET imaging of prostate cancer

Ga-peptide complexes m/z a m/z calculated as [M + H] + AnalyticalHPLC retention (min) b Affinity-related IC 50determined in enzyme-based assay (nM) c Affinity-related IC 50determined in cell-based assay (nM) c
[Ga]6 947.4257 947.4250 3.1 9.0 ± 1.1 12.1 ± 2.1
[Ga]7 1,361.6387 1,361.6364 3.1 2.1 ± 1.4 3.8 ± 1.8
  1. aHigh-resolution mass spectrometry data of the free ligands ([M + H]+); bcompounds were labeled with 68Ga; runs were performed using a linear A-B gradient (0% B to 100% B in 6 min) at a flow rate of 4 mL/min; solvent A was 0.1% aqueous TFA, and solvent B was MeOH; ccompounds were complexed with natGa.