Figure 5From: FDG-PET is a good biomarker of both early response and acquired resistance in BRAFV600 mutant melanomas treated with vemurafenib and the MEK inhibitor GDC-0973 Effects of BRAF and MEK on pathway proteins. Vemurafenib treatment induced reductions of the MAPK pathway in A375s but caused increases in MAPK and glucose metabolism/signaling resistant A375 R1s. Western blot analysis of PET-imaged tumors that had been treated with drug for 6 days is shown.Back to article page