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EJNMMI Research
Figure 2 | EJNMMI Research

Figure 2

From: FDG-PET is a good biomarker of both early response and acquired resistance in BRAFV600 mutant melanomas treated with vemurafenib and the MEK inhibitor GDC-0973

Figure 2

BRAF and MEK modulation of GLUT-1. BRAF and MEK inhibition results in changes in the amount of GLUT-1 at the cellular membrane associated with levels of FDG uptake. Immunofluorescent staining was performed for GLUT-1 (green) and nuclei (blue) on all panels of cells from Figure 1, which had been treated with drug for 3 days. (A) A375s, (B) resistant clone A375R1, (C) SK-Mel-30 melanomas and (D) HCT 116 colorectal cells.

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