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Figure 1 | EJNMMI Research

Figure 1

From: Co-registration of glucose metabolism with positron emission tomography and vascularity with fluorescent diffuse optical tomography in mouse tumors

Figure 1

Outline of the automatic co-registration method for optical and micro-PET images. (A) View of the multimodality mouse support system showing the four Plexiglas cubes containing the fiducial markers (FM). (B) Planar white light image of the subject used for the extraction of the planar coordinates of the FM. (C) Optical surface image used for the extraction of the z (vertical) coordinates of the FM (z 0opt). (D) A stack of coronal PET slices that correspond to the different z positions. (E) Projection image of the PET volume signal. The localization of the FM where their coordinates correspond to the radiation signal (x PET, y PET, z PET) is highlighted by dotted yellow rectangles. (F) Bird's eye view of the optical image of the mouse. (G) Bird's eye view of the micro-PET volume image. (H) Assembled image of the co-registered optical 3-D PET images. The image shows the coronal view of the animal with signals from both modalities, while the sagittal view depicts only the PET signal. Four zoom images of the co-registered FM are shown at the four corners of the image.

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