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Table 5 The total distribution volume obtained by the 2TCM and linear graphical methods

From: Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects

Brain region

V T (2TCM)

Error range (%)

Error (%) mean(SD)

V T Logan

Error range (%)

Error (%) mean(SD)

Caudate

0.88(0.13) to 1.06 (0.24)

-35 to 62

25(36)

0.64(0.16) to 0.59(0.19)

-37 to 25

-5(23)

Putamen

0.83(0.21) to 0.93(0.19)

-32 to 78

17(38)

0.70(0.15) to 0.73(0.26)

-25 to 42

3(25)

Thalamus

0.90(0.27) to 0.80 (0.23)

-47 to 40

-6(29)

0.80(0.24) to 0.76(0.25)

-26 to 27

-3(20)

Brainstem

0.86(0.18) to 0.74 (0.16)

-29 to -1

-13(10)

0.74(0.21) to 0.67(0.19)

-24 to 12

-8(12)

Cerebellum

0.74(0.18) to 0.72 (0.16)

-32 to 24

-1(18)

0.72(0.18) to 0.68(0.18)

-29 to 20

-4(18)

Grey matter

0.76(0.18) to 0.70 (0.17)

-36 to 15

-6(17)

0.69(0.17) to 0.65(0.18)

-28 to 17

-4(16)

White matter

0.99(0.17) to 0.88 (0.19)

-42 to 28

-9(25)

0.69(0.18) to 0.65(0.20)

-32 to 19

-4(19)

Whole brain

0.82(0.18) to 0.75 (0.16)

-38 to 21

-7(20)

0.69(0.17) to 0.65(0.19)

-29 to 17

-4(16)

  1. Values presented as mean(SD). Test-retest values are presented. V T (2TCM) is the distribution volume of two-tissue compartment model, K 1/k 2 (1 + k 3/k 4). V T Logan is the distribution volume obtained using the arterial input curve and linear graphical analysis. SD, standard deviation