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Table 5 The total distribution volume obtained by the 2TCM and linear graphical methods

From: Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects

Brain region V T (2TCM) Error range (%) Error (%) mean(SD) V T Logan Error range (%) Error (%) mean(SD)
Caudate 0.88(0.13) to 1.06 (0.24) -35 to 62 25(36) 0.64(0.16) to 0.59(0.19) -37 to 25 -5(23)
Putamen 0.83(0.21) to 0.93(0.19) -32 to 78 17(38) 0.70(0.15) to 0.73(0.26) -25 to 42 3(25)
Thalamus 0.90(0.27) to 0.80 (0.23) -47 to 40 -6(29) 0.80(0.24) to 0.76(0.25) -26 to 27 -3(20)
Brainstem 0.86(0.18) to 0.74 (0.16) -29 to -1 -13(10) 0.74(0.21) to 0.67(0.19) -24 to 12 -8(12)
Cerebellum 0.74(0.18) to 0.72 (0.16) -32 to 24 -1(18) 0.72(0.18) to 0.68(0.18) -29 to 20 -4(18)
Grey matter 0.76(0.18) to 0.70 (0.17) -36 to 15 -6(17) 0.69(0.17) to 0.65(0.18) -28 to 17 -4(16)
White matter 0.99(0.17) to 0.88 (0.19) -42 to 28 -9(25) 0.69(0.18) to 0.65(0.20) -32 to 19 -4(19)
Whole brain 0.82(0.18) to 0.75 (0.16) -38 to 21 -7(20) 0.69(0.17) to 0.65(0.19) -29 to 17 -4(16)
  1. Values presented as mean(SD). Test-retest values are presented. V T (2TCM) is the distribution volume of two-tissue compartment model, K 1/k 2 (1 + k 3/k 4). V T Logan is the distribution volume obtained using the arterial input curve and linear graphical analysis. SD, standard deviation