Table 4 Test-retest characteristics of [11C](R)-PK11195 binding to the TSPO in healthy subjects
Brain region | BP ND (k 3 /k 4) | Error range (%) | Error % mean(SD) | ICC | ||||
|---|---|---|---|---|---|---|---|---|
Test | CV (%) | Retest | CV (%) | Mean | ||||
Caudate | 1.37(0.55) | 40 | 1.92(0.87) | 45 | 1.65 | -155 to 30 | -55(80) | 0.01 |
Caudate (R) | 1.33(0.68) | 51 | 2.21(1.19) | 54 | 1.77 | -288 to12 | -96(126) | 0.01 |
Caudate (L) | 1.52(0.43) | 28 | 1.84(0.93) | 51 | 1.68 | -133 to 42 | -27(66) | -0.05 |
Putamen | 1.20(0.28) | 24 | 1.50(0.69) | 46 | 1.38 | -138 to 21 | -25(63) | 0.09 |
Putamen (R) | 1.27(0.48) | 37 | 1.56(0.73) | 47 | 1.41 | -145 to 34 | -32(72) | -0.01 |
Putamen (L) | 1.28(0.31) | 24 | 1.60(0.67) | 42 | 1.44 | -145 to 23 | -30(59) | 0.02 |
Thalamus | 1.19(0.28) | 23 | 1.53(0.45) | 30 | 1.36 | -82 to 9 | -29(33) | 0.57 |
Thalamus (R) | 1.34(0.43) | 32 | 1.86(0.56) | 30 | 1.60 | -136 to 17 | -46(50) | 0.16 |
Thalamus (L) | 1.11(0.25) | 23 | 1.42(0.59) | 42 | 1.26 | -136 to 39 | -32(64) | 0.17 |
Brainstem | 2.00(0.35) | 17 | 2.18(0.33) | 15 | 2.09 | -45 to 26 | -13(31) | -0.6 |
Cerebellum | 1.29(0.19) | 15 | 1.37(0.24) | 17 | 1.33 | -21 to 32 | -8(20) | 0.07 |
White matter | 1.90(0.42) | 22 | 1.78(0.42) | 24 | 1.84 | -25 to 21 | -8(18) | 0.73 |
Grey matter, cortex | 1.50(0.27) | 18 | 1.59(0.29) | 18 | 1.55 | -24 to 25 | 5(18) | 0.47 |
Whole brain | 1.65(0.33) | 20 | 1.68(0.35) | 21 | 1.67 | -25 to 22 | -4(19) | 0.57 |