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Table 4 Test-retest characteristics of [11C](R)-PK11195 binding to the TSPO in healthy subjects

From: Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects

Brain region    BP ND (k 3 /k 4)    Error range (%) Error % mean(SD) ICC
  Test CV (%) Retest CV (%) Mean    
Caudate 1.37(0.55) 40 1.92(0.87) 45 1.65 -155 to 30 -55(80) 0.01
   Caudate (R) 1.33(0.68) 51 2.21(1.19) 54 1.77 -288 to12 -96(126) 0.01
   Caudate (L) 1.52(0.43) 28 1.84(0.93) 51 1.68 -133 to 42 -27(66) -0.05
Putamen 1.20(0.28) 24 1.50(0.69) 46 1.38 -138 to 21 -25(63) 0.09
   Putamen (R) 1.27(0.48) 37 1.56(0.73) 47 1.41 -145 to 34 -32(72) -0.01
   Putamen (L) 1.28(0.31) 24 1.60(0.67) 42 1.44 -145 to 23 -30(59) 0.02
Thalamus 1.19(0.28) 23 1.53(0.45) 30 1.36 -82 to 9 -29(33) 0.57
   Thalamus (R) 1.34(0.43) 32 1.86(0.56) 30 1.60 -136 to 17 -46(50) 0.16
   Thalamus (L) 1.11(0.25) 23 1.42(0.59) 42 1.26 -136 to 39 -32(64) 0.17
Brainstem 2.00(0.35) 17 2.18(0.33) 15 2.09 -45 to 26 -13(31) -0.6
Cerebellum 1.29(0.19) 15 1.37(0.24) 17 1.33 -21 to 32 -8(20) 0.07
White matter 1.90(0.42) 22 1.78(0.42) 24 1.84 -25 to 21 -8(18) 0.73
Grey matter, cortex 1.50(0.27) 18 1.59(0.29) 18 1.55 -24 to 25 5(18) 0.47
Whole brain 1.65(0.33) 20 1.68(0.35) 21 1.67 -25 to 22 -4(19) 0.57
  1. Binding potential, BP ND = k 3 /k 4 from 2TCM; CV, coefficient of variance; ICC, intra-class correlations