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Table 3 Kinetic constants in 2TCM with shared K 1/k 2 values for [11C](R)-PK11195 binding in 6 healthy subjects

From: Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects

Subject K 1 (mL/cc/min) k 2 (min-1) k 3 (min-1) k 4 (min-1) K 1 /k 2 k 3 /k 4 (BP ND) AIC
Cortical grey matter       
1 0.092 0.236 0.055 0.054 0.39 1.02 170
2 0.070 0.228 0.046 0.025 0.31 1.82 173
3 0.089 0.307 0.124 0.061 0.29 2.01 195
4 0.046 0.185 0.035 0.026 0.25 1.36 180
5 0.080 0.235 0.036 0.020 0.34 1.80 183
6 0.050 0.180 0.021 0.014 0.28 1.47 204
Mean 0.071 0.228 0.053 0.033 0.31 1.58  
(SD/CV) (0.019/27) (0.046/20) (0.037/69) (0.019/57) (0.05/16) (0.36/23)  
White matter       
1 0.067 0.169 0.040 0.033 0.40 1.02 178
2 0.056 0.180 0.045 0.021 0.31 2.18 176
3 0.062 0.159 0.046 0.027 0.39 1.68 176
4 0.032 0.129 0.026 0.013 0.25 1.97 190
5 0.061 0.182 0.033 0.013 0.33 2.46 200
6 0.036 0.138 0.024 0.012 0.26 1.97 212
Mean 0.052 0.159 0.036 0.020 0.32 1.88  
(SD/CV) (0.015/29) (0.022/14) (0.009/25) (0.009/45) (0.06/19) (0.49/26)  
  1. Data from the first PET measurement only is presented for simplification purposes. SD, standard deviation; CV, coefficient of variation; AIC, Akaike information criteria