Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects

EJNMMI Research

Table 3 Kinetic constants in 2TCM with shared K ₁/k ₂ values for [¹¹C](R)-PK11195 binding in 6 healthy subjects

Subject	K ₁ (mL/cc/min)	k ₂ (min^-1)	k ₃ (min^-1)	k ₄ (min^-1)	K ₁ /k ₂	k ₃ /k ₄ (BP _ND)	AIC
Cortical grey matter
1	0.092	0.236	0.055	0.054	0.39	1.02	170
2	0.070	0.228	0.046	0.025	0.31	1.82	173
3	0.089	0.307	0.124	0.061	0.29	2.01	195
4	0.046	0.185	0.035	0.026	0.25	1.36	180
5	0.080	0.235	0.036	0.020	0.34	1.80	183
6	0.050	0.180	0.021	0.014	0.28	1.47	204
Mean	0.071	0.228	0.053	0.033	0.31	1.58
(SD/CV)	(0.019/27)	(0.046/20)	(0.037/69)	(0.019/57)	(0.05/16)	(0.36/23)
White matter
1	0.067	0.169	0.040	0.033	0.40	1.02	178
2	0.056	0.180	0.045	0.021	0.31	2.18	176
3	0.062	0.159	0.046	0.027	0.39	1.68	176
4	0.032	0.129	0.026	0.013	0.25	1.97	190
5	0.061	0.182	0.033	0.013	0.33	2.46	200
6	0.036	0.138	0.024	0.012	0.26	1.97	212
Mean	0.052	0.159	0.036	0.020	0.32	1.88
(SD/CV)	(0.015/29)	(0.022/14)	(0.009/25)	(0.009/45)	(0.06/19)	(0.49/26)

Data from the first PET measurement only is presented for simplification purposes. SD, standard deviation; CV, coefficient of variation; AIC, Akaike information criteria