Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects

EJNMMI Research

Table 2 Comparison of kinetic constants in 1TCM and 2TCM for [¹¹C](R)-PK11195 binding in the white matter

Subject	Test (1); retest (2)	Model	K ₁ (mL/cc/min)	k ₂ (min^-1)	k ₃ (min^-1)	k ₄ (min^-1)	K ₁ /k ₂	k ₃ /k ₄ (BP _ND)	AIC	F-statistics (1TCM/2TCM; p value)
1	1	1TCM	0.055	0.086			0.64		228
		2TCM	0.067	0.165	0.037	0.030	0.41	1.21	180	2 × 10^-10
	2	1TCM	0.042	0.071			0.59		250
		2TCM	0.051	0.144	0.033	0.022	0.35	1.49	198	3 × 10^-11
2	1	1TCM	0.044	0.071			0.61		244
		2TCM	0.056	0.176	0.043	0.019	0.32	2.20	177	4 × 10^-14
	2	1TCM	0.046	0.089			0.52		267
		2TCM	0.060	0.206	0.042	0.025	0.29	1.65	208	1 × 10^-12
3	1	1TCM	0.049	0.066			0.74		250
		2TCM	0.061	0.154	0.043	0.026	0.40	1.67	177	3 × 10^-15
	2	1TCM	0.075	0.085			0.88		278
		2TCM	0.097	0.209	0.061	0.045	0.61	1.36	212	7 × 10^-14
4	1	1TCM	0.027	0.066			0.41		223
		2TCM	0.032	0.124	0.024	0.019	0.26	2.03	192	3 × 10^-7
	2	1TCM	0.027	0.066			0.41		239
		2TCM	0.035	0.164	0.041	0.020	0.21	2.03	176	2 × 10^-13
5	1	1TCM	0.048	0.081			0.59		274
		2TCM	0.061	0.184	0.034	0.014	0.33	2.41	201	3 × 10^-15
	2	1TCM	0.032	0.078			0.41		273
		2TCM	0.045	0.223	0.046	0.019	0.20	2.50	208	1 × 10^-13
6	1	1TCM	0.030	0.072			0.41		255
		2TCM	0.035	0.138	0.024	0.012	0.25	1.91	213	2 × 10^-9
	2	1TCM	0.033	0.064			0.52		246
		2TCM	0.039	0.126	0.028	0.018	0.31	1.62	175	8 × 10^-15
Mean	1	1TCM	0.042(0.011/26)	0.074(0.008/11)			0.57(0.13/23)
(SD/CV)		2TCM	0.052(0.015/29)	0.157(0.02/13)	0.034(0.009/26)	0.020(0.007/35)	0.33(0.07/20)	1.93(0.48/22)
	2	1TCM	0.043(0.017/39)	0.076(0.010/13)			0.56(0.18/32)
		2TCM	0.055(0.023/42)	0.179(0.040/22)	0.042(0.011/26)	0.025(0.010/40)	0.31(0.10/32)	1.78(0.42/24)

Data from the first PET measurement used for all subjects. 1TCM, one-tissue compartment model; 2TCM, two-tissue compartment model; SD, standard deviation; CV, coefficient of variation; AIC, Akaike information criteria