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Table 2 Comparison of kinetic constants in 1TCM and 2TCM for [11C](R)-PK11195 binding in the white matter

From: Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects

Subject Test (1); retest (2) Model K 1 (mL/cc/min) k 2 (min-1) k 3 (min-1) k 4 (min-1) K 1 /k 2 k 3 /k 4 (BP ND) AIC F-statistics (1TCM/2TCM; p value)
1 1 1TCM 0.055 0.086    0.64   228  
   2TCM 0.067 0.165 0.037 0.030 0.41 1.21 180 2 × 10-10
  2 1TCM 0.042 0.071    0.59   250  
   2TCM 0.051 0.144 0.033 0.022 0.35 1.49 198 3 × 10-11
2 1 1TCM 0.044 0.071    0.61   244  
   2TCM 0.056 0.176 0.043 0.019 0.32 2.20 177 4 × 10-14
  2 1TCM 0.046 0.089    0.52   267  
   2TCM 0.060 0.206 0.042 0.025 0.29 1.65 208 1 × 10-12
3 1 1TCM 0.049 0.066    0.74   250  
   2TCM 0.061 0.154 0.043 0.026 0.40 1.67 177 3 × 10-15
  2 1TCM 0.075 0.085    0.88   278  
   2TCM 0.097 0.209 0.061 0.045 0.61 1.36 212 7 × 10-14
4 1 1TCM 0.027 0.066    0.41   223  
   2TCM 0.032 0.124 0.024 0.019 0.26 2.03 192 3 × 10-7
  2 1TCM 0.027 0.066    0.41   239  
   2TCM 0.035 0.164 0.041 0.020 0.21 2.03 176 2 × 10-13
5 1 1TCM 0.048 0.081    0.59   274  
   2TCM 0.061 0.184 0.034 0.014 0.33 2.41 201 3 × 10-15
  2 1TCM 0.032 0.078    0.41   273  
   2TCM 0.045 0.223 0.046 0.019 0.20 2.50 208 1 × 10-13
6 1 1TCM 0.030 0.072    0.41   255  
   2TCM 0.035 0.138 0.024 0.012 0.25 1.91 213 2 × 10-9
  2 1TCM 0.033 0.064    0.52   246  
   2TCM 0.039 0.126 0.028 0.018 0.31 1.62 175 8 × 10-15
Mean 1 1TCM 0.042(0.011/26) 0.074(0.008/11)    0.57(0.13/23)    
(SD/CV)   2TCM 0.052(0.015/29) 0.157(0.02/13) 0.034(0.009/26) 0.020(0.007/35) 0.33(0.07/20) 1.93(0.48/22)   
  2 1TCM 0.043(0.017/39) 0.076(0.010/13)    0.56(0.18/32)    
   2TCM 0.055(0.023/42) 0.179(0.040/22) 0.042(0.011/26) 0.025(0.010/40) 0.31(0.10/32) 1.78(0.42/24)   
  1. Data from the first PET measurement used for all subjects. 1TCM, one-tissue compartment model; 2TCM, two-tissue compartment model; SD, standard deviation; CV, coefficient of variation; AIC, Akaike information criteria