Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects

EJNMMI Research

Table 1 Comparison of kinetic constants in 1TCM and 2TCM for [¹¹C](R)-PK11195 binding in the grey matter

Subject	Test (1); retest (2)	Model	K ₁ (mL/cc/min)	k ₂ (min^-1)	k ₃ (min^-1)	k ₄ (min^-1)	K ₁ /k ₂	k ₃ /k ₄ (BP _ND)	AIC	F-statistics (1TCM/2TCM; p value)
1	1	1TCM	0.074	0.116			0.64		239
		2TCM	0.094	0.264	0.076	0.067	0.36	1.13	171	3 × 10^-14
	2	1TCM	0.056	0.099			0.57		264
		2TCM	0.073	0.234	0.059	0.044	0.31	1.33	197	4 × 10^-14
2	1	1TCM	0.054	0.096			0.55		253
		2TCM	0.072	0.252	0.058	0.026	0.28	1.86	173	1 × 10^-16
	2	1TCM	0.057	0.118			0.48		274
		2TCM	0.077	0.287	0.059	0.041	0.27	1.44	211	2 × 10^-13
3	1	1TCM	0.062	0.086			0.72		264
		2TCM	0.082	0.220	0.061	0.033	0.39	1.55	181	< 1 × 10^-323
	2	1TCM	0.094	0.111			0.84		286
		2TCM	0.129	0.318	0.111	0.076	0.41	1.47	210	9 × 10^-16
4	1	1TCM	0.037	0.087			0.41		236
		2TCM	0.048	0.220	0.055	0.038	0.22	1.45	179	3 × 10^-12
	2	1TCM	0.035	0.086			0.41		236
		2TCM	0.049	0.246	0.062	0.035	0.20	1.80	178	2 × 10^-12
5	1	1TCM	0.062	0.111			0.56		283
		2TCM	0.082	0.245	0.040	0.023	0.33	1.75	184	< 1 × 10^-323
	2	1TCM	0.044	0.108			0.41		288
		2TCM	0.067	0.340	0.068	0.032	0.20	2.08	204	< 1 × 10^-323
6	1	1TCM	0.042	0.106			0.39		267
		2TCM	0.054	0.221	0.038	0.029	0.24	1.27	197	1 × 10^-4
	2	1TCM	0.045	0.091			0.49		272
		2TCM	0.060	0.239	0.065	0.045	0.25	1.44	231	3 × 10^-9
Mean	1	1TCM	0.055(0.014/25)	0.100(0.012/12)			0.54(0.13/23)	Mean	1	1TCM
(SD/CV)		2TCM	0.072(0.018/25)	0.237(0.019/8)	0.055(0.014/25)	0.029(0.011/38)	0.30(0.06/21)	1.50(0.27/18)	(SD/CV)
	2	1TCM	0.055(0.021/18)	0.102(0.012/12)			0.53(0.16/31)
		2TCM	0.076 (0.028/37)	0.277(0.045/16)	0.071(0.02/28)	0.046(0.016/34)	0.27(0.08/29)	1.59(0.29/18)

Data from the first PET measurement used for all subjects. 1TCM, one-tissue compartment model; 2TCM, two-tissue compartment model; SD, standard deviation; CV, coefficient of variation; AIC, Akaike information criteria