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Table 1 Comparison of kinetic constants in 1TCM and 2TCM for [11C](R)-PK11195 binding in the grey matter

From: Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects

Subject Test (1); retest (2) Model K 1 (mL/cc/min) k 2 (min-1) k 3 (min-1) k 4 (min-1) K 1 /k 2 k 3 /k 4 (BP ND) AIC F-statistics (1TCM/2TCM; p value)
1 1 1TCM 0.074 0.116    0.64   239  
   2TCM 0.094 0.264 0.076 0.067 0.36 1.13 171 3 × 10-14
  2 1TCM 0.056 0.099    0.57   264  
   2TCM 0.073 0.234 0.059 0.044 0.31 1.33 197 4 × 10-14
2 1 1TCM 0.054 0.096    0.55   253  
   2TCM 0.072 0.252 0.058 0.026 0.28 1.86 173 1 × 10-16
  2 1TCM 0.057 0.118    0.48   274  
   2TCM 0.077 0.287 0.059 0.041 0.27 1.44 211 2 × 10-13
3 1 1TCM 0.062 0.086    0.72   264  
   2TCM 0.082 0.220 0.061 0.033 0.39 1.55 181 < 1 × 10-323
  2 1TCM 0.094 0.111    0.84   286  
   2TCM 0.129 0.318 0.111 0.076 0.41 1.47 210 9 × 10-16
4 1 1TCM 0.037 0.087    0.41   236  
   2TCM 0.048 0.220 0.055 0.038 0.22 1.45 179 3 × 10-12
  2 1TCM 0.035 0.086    0.41   236  
   2TCM 0.049 0.246 0.062 0.035 0.20 1.80 178 2 × 10-12
5 1 1TCM 0.062 0.111    0.56   283  
   2TCM 0.082 0.245 0.040 0.023 0.33 1.75 184 < 1 × 10-323
  2 1TCM 0.044 0.108    0.41   288  
   2TCM 0.067 0.340 0.068 0.032 0.20 2.08 204 < 1 × 10-323
6 1 1TCM 0.042 0.106    0.39   267  
   2TCM 0.054 0.221 0.038 0.029 0.24 1.27 197 1 × 10-4
  2 1TCM 0.045 0.091    0.49   272  
   2TCM 0.060 0.239 0.065 0.045 0.25 1.44 231 3 × 10-9
Mean 1 1TCM 0.055(0.014/25) 0.100(0.012/12)    0.54(0.13/23) Mean 1 1TCM
(SD/CV)   2TCM 0.072(0.018/25) 0.237(0.019/8) 0.055(0.014/25) 0.029(0.011/38) 0.30(0.06/21) 1.50(0.27/18) (SD/CV)  
  2 1TCM 0.055(0.021/18) 0.102(0.012/12)    0.53(0.16/31)    
   2TCM 0.076 (0.028/37) 0.277(0.045/16) 0.071(0.02/28) 0.046(0.016/34) 0.27(0.08/29) 1.59(0.29/18)   
  1. Data from the first PET measurement used for all subjects. 1TCM, one-tissue compartment model; 2TCM, two-tissue compartment model; SD, standard deviation; CV, coefficient of variation; AIC, Akaike information criteria