| |
Mice
| |
Rats
| | | |
|---|
| |
Mdr1a/1b
|
WT
|
FMZ
|
FMZ
|
FMZ
|
FMZ
|
| |
dKO
| |
dose 4 μg
|
dose 20
|
dose 100
|
dose 400
|
| | | | |
μg
|
μg
|
μg
|
|
Number (n)
| | | | | | |
|
Scan 1
|
10
|
9
|
3
|
3
|
2
|
2
|
|
Scan 2
|
6
|
6
|
3
|
3
|
2
|
2
|
|
Animal weight (g)
|
31 ± 2
|
26 ± 2
|
283 ± 24
|
267 ± 11
|
260, 293
|
265, 270
|
|
Radioactivity
| | | | | | |
|
[11C]FMZ (MBq)
| | | | | | |
|
Scan 1
|
7.3 ± 3.0
|
6.5 ± 2.0
|
31 ± 8
|
24 ± 9
|
30, 34
|
18, 20
|
|
Scan 2
|
7.0 ± 1.5
|
7.8 ± 2.0
|
21 ± 5
|
18 ± 2
|
16, 26
|
21, 16
|
|
Exact FMZ dose
| | | | | | |
|
(μg)
| | | | | | |
|
Scan 1
|
td
|
td
|
3.6 ± 0.1
|
16.3 ± 0.2
|
83, 87
|
366, 424
|
|
Scan 2
|
td
|
td
|
3.9 ± 0.1
|
17.9 ± 1.0
|
85, 89
|
391, 458
|
- Abbreviations: dKO double knockout, WT wild type, FMZ flumazenil, td tracer dose (< 0.1 μg).
