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Table 1 Number of mice/rats, together with average (± standard deviation) weight, dose of flumazenil and radioactivity administered

From: [11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein

  Mice   Rats    
  Mdr1a/1b WT FMZ FMZ FMZ FMZ
  dKO   dose 4 μg dose 20 dose 100 dose 400
     μg μg μg
Number (n)       
Scan 1 10 9 3 3 2 2
Scan 2 6 6 3 3 2 2
Animal weight (g) 31 ± 2 26 ± 2 283 ± 24 267 ± 11 260, 293 265, 270
Radioactivity       
[11C]FMZ (MBq)       
Scan 1 7.3 ± 3.0 6.5 ± 2.0 31 ± 8 24 ± 9 30, 34 18, 20
Scan 2 7.0 ± 1.5 7.8 ± 2.0 21 ± 5 18 ± 2 16, 26 21, 16
Exact FMZ dose       
(μg)       
Scan 1 td td 3.6 ± 0.1 16.3 ± 0.2 83, 87 366, 424
Scan 2 td td 3.9 ± 0.1 17.9 ± 1.0 85, 89 391, 458
  1. Abbreviations: dKO double knockout, WT wild type, FMZ flumazenil, td tracer dose (< 0.1 μg).