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Table 1 Number of mice/rats, together with average (± standard deviation) weight, dose of flumazenil and radioactivity administered

From: [11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein

 

Mice

 

Rats

   
 

Mdr1a/1b

WT

FMZ

FMZ

FMZ

FMZ

 

dKO

 

dose 4 μg

dose 20

dose 100

dose 400

    

μg

μg

μg

Number (n)

      

Scan 1

10

9

3

3

2

2

Scan 2

6

6

3

3

2

2

Animal weight (g)

31 ± 2

26 ± 2

283 ± 24

267 ± 11

260, 293

265, 270

Radioactivity

      

[11C]FMZ (MBq)

      

Scan 1

7.3 ± 3.0

6.5 ± 2.0

31 ± 8

24 ± 9

30, 34

18, 20

Scan 2

7.0 ± 1.5

7.8 ± 2.0

21 ± 5

18 ± 2

16, 26

21, 16

Exact FMZ dose

      

(μg)

      

Scan 1

td

td

3.6 ± 0.1

16.3 ± 0.2

83, 87

366, 424

Scan 2

td

td

3.9 ± 0.1

17.9 ± 1.0

85, 89

391, 458

  1. Abbreviations: dKO double knockout, WT wild type, FMZ flumazenil, td tracer dose (< 0.1 μg).