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Table 3 Absolute values and test-retest variability of various quantitative PET measures obtained with various registration strategies

From: Effects of rigid and non-rigid image registration on test-retest variability of quantitative [18F]FDG PET/CT studies

Measure Transfor mation Input data Focus Absolute valuesa Absolute test-retes variability t Relative test-retest variability
     Mean Median Range Mean Median P- value b Mean Median P- value b
SUVmax Referencec    17.5 14.5 4.6 - 46.4 10.7 10.0 - -3.4 -3.5 -
  Rigid PET Global 17.4 14.5 4.6 - 46.4 11.5 10.0 0.197 -3.4 -3.5 1.000
    Local 17.4 14.5 4.6 - 46.4 11.3 10.2 0.988 -2.8 -3.5 0.855
   CT Global 17.3 14.5 3.5 - 46.4 13.0 14.8 0.331 -1.0 -3.5 0.900
    Local 17.4 14.5 4.6 - 46.4 11.9 12.5 0.684 -2.2 -3.5 0.768
  Non-rigid PET Global 17.5 14.5 4.6 - 46.4 10.8 10.0 0.812 -3.4 -3.5 0.136
   CT Global 17.5 14.5 4.6 - 46.4 10.8 10.0 0.768 -3.4 -3.5 0.410
   CTPET Global 17.5 14.5 4.6 - 46.4 10.8 10.0 0.812 -3.4 -3.5 0.136
SUVmean Referencec    11.6 9.5 3.1 - 30.5 12.6 13.3 - -2.7 -5.7 -
  Rigid PET Global 10.3 8.2 2.2 - 29.5 20.8 12.5 0.229 14.3 9.1 < 0.001d
    Local 10.9 8.9 2.2 - 29.5 16.9 13.6 0.264 7.1 2.4 0.037d
   CT Global 10.4 8.2 1.5 - 28.2 18.3 9.0 0.527 12.1 6.3 < 0.001d
    Local 10.4 8.3 2.8 - 27.9 17.3 11.8 0.998 11.1 8.7 0.015d
  Non-rigid PET Global 11.1 8.8 3.2 - 29.4 10.2 9.1 0.074 1.2 -0.7 0.001d
   CT Global 10.2 8.3 2.8 - 22.8 13.6 10.5 0.989 8.7 7.0 < 0.001d
   CTPET Global 11.2 9.0 3.2 - 29.4 10.8 10.8 0.049d 0.4 -1.4 0.004d
Metaboli Referencec    63.9 16.7 1.1 - 749 18.4 16.0 - 0.3 -3.6 -
c volume Rigid PET Global 61.6 25.1 1.0 - 711 0.1 0.0 < 0.001d 0.0 0.0 0.989
    Local 61.6 25.3 1.0 - 711 0.4 0.0 < 0.001d 0.4 0.0 0.900
   CT Global 61.6 25.3 1.0 - 711 0.1 0.0 < 0.001d -0.1 0.0 0.989
    Local 61.5 25.2 1.0 - 710 0.8 0.0 < 0.001d 0.4 0.0 0.900
  Non-rigid PET Global 66.2 23.2 1.2 - 809 11.7 7.7 0.101 -1.0 -2.4 0.509
   CT Global 60.1 24.8 1.2 - 686 9.2 6.0 0.034d 2.7 1.6 0.584
   CTPET Global 66.1 23.4 1.0 - 810 11.7 7.2 0.011d 2.0 -0.4 1.000
TLG Referencec    713 191 11.1 - 6641 19.2 14.1 - -2.5 -7.3 -
  Rigid PET Global 644 168 7.0 - 6051 20.9 12.6 0.812 14.3 9.0 0.007d
    Local 662 175 7.0 - 6184 17.1 13.6 0.603 7.3 2.2 0.074
   CT Global 635 160 4.7 - 5845 18.3 9.1 0.406 12.1 6.2 0.031d
    Local 632 162 8.6 - 5834 17.6 11.8 0.049d 11.5 8.3 0.015d
  Non-rigid PET Global 709 184 7.1 - 6944 19.1 16.7 0.966 0.1 -0.6 0.967
   CT Global 607 152 8.7 - 5652 18.4 15.8 0.790 11.3 8.3 0.005d
   CTPET Global 708 181 8.0 - 6957 18.1 14.2 0.768 2.4 0.0 0.345
  1. aUnits of absolute values, obtained from the retest scan, were g/ml, g/ml, ml and g for SUVmax, SUVmean, metabolic volume and TLG, respectively. bP-values were calculated from data obtained with registration strategy and reference (test-retest variability values that were obtained by delineating VOIs on both scans separately). cReference illustrates those test-retest variability values that were obtained by delineating VOIs on both scans separately. dStatistically significant difference (P < 0.05); TLG = total lesion glycolysis; VOI = volume of interest