Effects of rigid and non-rigid image registration on test-retest variability of quantitative [18F]FDG PET/CT studies

van Velden, Floris HP; van Beers, Paul; Nuyts, Johan; Velasquez, Linda M; Hayes, Wendy; Lammertsma, Adriaan A; Boellaard, Ronald; Loeckx, Dirk

doi:10.1186/2191-219X-2-10

EJNMMI Research

Table 3 Absolute values and test-retest variability of various quantitative PET measures obtained with various registration strategies

From: Effects of rigid and non-rigid image registration on test-retest variability of quantitative [¹⁸F]FDG PET/CT studies

Measure	Transfor mation	Input data	Focus	Absolute values^a			Absolute test-retes variability t			Relative test-retest variability
				Mean	Median	Range	Mean	Median	P- value ^b	Mean	Median	P- value ^b
SUV_max	Reference^c			17.5	14.5	4.6 - 46.4	10.7	10.0	-	-3.4	-3.5	-
	Rigid	PET	Global	17.4	14.5	4.6 - 46.4	11.5	10.0	0.197	-3.4	-3.5	1.000
			Local	17.4	14.5	4.6 - 46.4	11.3	10.2	0.988	-2.8	-3.5	0.855
		CT	Global	17.3	14.5	3.5 - 46.4	13.0	14.8	0.331	-1.0	-3.5	0.900
			Local	17.4	14.5	4.6 - 46.4	11.9	12.5	0.684	-2.2	-3.5	0.768
	Non-rigid	PET	Global	17.5	14.5	4.6 - 46.4	10.8	10.0	0.812	-3.4	-3.5	0.136
		CT	Global	17.5	14.5	4.6 - 46.4	10.8	10.0	0.768	-3.4	-3.5	0.410
		CTPET	Global	17.5	14.5	4.6 - 46.4	10.8	10.0	0.812	-3.4	-3.5	0.136
SUVmean	Reference^c			11.6	9.5	3.1 - 30.5	12.6	13.3	-	-2.7	-5.7	-
	Rigid	PET	Global	10.3	8.2	2.2 - 29.5	20.8	12.5	0.229	14.3	9.1	< 0.001^d
			Local	10.9	8.9	2.2 - 29.5	16.9	13.6	0.264	7.1	2.4	0.037^d
		CT	Global	10.4	8.2	1.5 - 28.2	18.3	9.0	0.527	12.1	6.3	< 0.001^d
			Local	10.4	8.3	2.8 - 27.9	17.3	11.8	0.998	11.1	8.7	0.015^d
	Non-rigid	PET	Global	11.1	8.8	3.2 - 29.4	10.2	9.1	0.074	1.2	-0.7	0.001^d
		CT	Global	10.2	8.3	2.8 - 22.8	13.6	10.5	0.989	8.7	7.0	< 0.001^d
		CTPET	Global	11.2	9.0	3.2 - 29.4	10.8	10.8	0.049^d	0.4	-1.4	0.004^d
Metaboli	Reference^c			63.9	16.7	1.1 - 749	18.4	16.0	-	0.3	-3.6	-
c volume	Rigid	PET	Global	61.6	25.1	1.0 - 711	0.1	0.0	< 0.001^d	0.0	0.0	0.989
			Local	61.6	25.3	1.0 - 711	0.4	0.0	< 0.001^d	0.4	0.0	0.900
		CT	Global	61.6	25.3	1.0 - 711	0.1	0.0	< 0.001^d	-0.1	0.0	0.989
			Local	61.5	25.2	1.0 - 710	0.8	0.0	< 0.001^d	0.4	0.0	0.900
	Non-rigid	PET	Global	66.2	23.2	1.2 - 809	11.7	7.7	0.101	-1.0	-2.4	0.509
		CT	Global	60.1	24.8	1.2 - 686	9.2	6.0	0.034^d	2.7	1.6	0.584
		CTPET	Global	66.1	23.4	1.0 - 810	11.7	7.2	0.011^d	2.0	-0.4	1.000
TLG	Reference^c			713	191	11.1 - 6641	19.2	14.1	-	-2.5	-7.3	-
	Rigid	PET	Global	644	168	7.0 - 6051	20.9	12.6	0.812	14.3	9.0	0.007^d
			Local	662	175	7.0 - 6184	17.1	13.6	0.603	7.3	2.2	0.074
		CT	Global	635	160	4.7 - 5845	18.3	9.1	0.406	12.1	6.2	0.031^d
			Local	632	162	8.6 - 5834	17.6	11.8	0.049^d	11.5	8.3	0.015^d
	Non-rigid	PET	Global	709	184	7.1 - 6944	19.1	16.7	0.966	0.1	-0.6	0.967
		CT	Global	607	152	8.7 - 5652	18.4	15.8	0.790	11.3	8.3	0.005^d
		CTPET	Global	708	181	8.0 - 6957	18.1	14.2	0.768	2.4	0.0	0.345

^aUnits of absolute values, obtained from the retest scan, were g/ml, g/ml, ml and g for SUV_max, SUV_mean, metabolic volume and TLG, respectively. ^bP-values were calculated from data obtained with registration strategy and reference (test-retest variability values that were obtained by delineating VOIs on both scans separately). ^cReference illustrates those test-retest variability values that were obtained by delineating VOIs on both scans separately. ^dStatistically significant difference (P < 0.05); TLG = total lesion glycolysis; VOI = volume of interest

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