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EJNMMI Research

Table 3 Nicotine dose effects on 18F-nifene binding

From: Evaluation of 18F-nifene binding to α4β2 nicotinic receptors in the rat brain using microPET imaging

Nicotine, mg/kg

% Injected dose/cc

thalamus

Nicotine

occupancy

0

0.489

0%

0.02

0.092

81%

0.10

0.037

92%

0.25

0.031

94%

0.50

0.005

99%

  1. Average of two measurements for each dose; receptor occupancy was calculated on the basis of percent injected dose per cubic centimeter of 18F-nifene in the thalamus (Thalcont - Thalnic/Thalcont × 100).
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