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Table 3 Nicotine dose effects on 18F-nifene binding

From: Evaluation of 18F-nifene binding to α4β2 nicotinic receptors in the rat brain using microPET imaging

Nicotine, mg/kg % Injected dose/cc
thalamus
Nicotine
occupancy
0 0.489 0%
0.02 0.092 81%
0.10 0.037 92%
0.25 0.031 94%
0.50 0.005 99%
  1. Average of two measurements for each dose; receptor occupancy was calculated on the basis of percent injected dose per cubic centimeter of 18F-nifene in the thalamus (Thalcont - Thalnic/Thalcont × 100).