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Table 2 Measured 18F-nifene ratios of rat brain regions with reference to the cerebellum

From: Evaluation of 18F-nifene binding to α4β2 nicotinic receptors in the rat brain using microPET imaging

Brain regions In vivo microPETa Ex vivo microPETb Ex vivo autoradiographsc
Thalamus 3.13 ± 0.29 3.92 ± 0.49 4.60 ± 0.52
Subiculum - 2.28 ± 0.24 2.39 ± 0.15
Cortex 1.98 ± 0.10 2.05 ± 0.17 1.83 ± 0.19
Striatum 1.52 ± 0.39 1.77 ± 0.28 1.46 ± 0.07
  1. Average of four animals with standard deviations; aRatio measured at 85-90 min postinjection of 18F-nifene; bRatio measured in the 60-min summed ex vivo scan of the same rats; cRatios measured in sections after the ex vivo scans of the same rats.