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EJNMMI Research

Table 2 Measured 18F-nifene ratios of rat brain regions with reference to the cerebellum

From: Evaluation of 18F-nifene binding to α4β2 nicotinic receptors in the rat brain using microPET imaging

Brain regions

In vivo microPETa

Ex vivo microPETb

Ex vivo autoradiographsc

Thalamus

3.13 ± 0.29

3.92 ± 0.49

4.60 ± 0.52

Subiculum

-

2.28 ± 0.24

2.39 ± 0.15

Cortex

1.98 ± 0.10

2.05 ± 0.17

1.83 ± 0.19

Striatum

1.52 ± 0.39

1.77 ± 0.28

1.46 ± 0.07

  1. Average of four animals with standard deviations; aRatio measured at 85-90 min postinjection of 18F-nifene; bRatio measured in the 60-min summed ex vivo scan of the same rats; cRatios measured in sections after the ex vivo scans of the same rats.
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