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Figure 5 | EJNMMI Research

Figure 5

From: Evaluation of 18F-nifene binding to α4β2 nicotinic receptors in the rat brain using microPET imaging

Figure 5

In vivo displacement of 18 F-nifene by nicotine. In vivo rat microPET brain slices of 18F-nifene before (A) and after (B) nicotine challenge. (C) Time-activity curve of 18F-nifene specific binding (thalamus-cerebellum) with nicotine (0.3 mg/kg) administered at 30 min pi, displacing 18F-nifene binding in the thalamus (inset shows dissociation rate, koff of 18F-nifene was 0.06 min-1).

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