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Table 2 Binding potential of [N-methyl-11C]mirtazapine estimated using six methods

From: PET kinetics of radiolabeled antidepressant, [N-methyl-11C]mirtazapine, in the human brain

Method Region Subject
   1 2 3 4 5
A 2 0.44 0.41 0.78 0.54 0.56
  3 0.99 0.78 0.99 1.00 0.80
  4 0.36 0.34 0.94 0.47 0.57
  5 0.40 0.36 0.69 0.51 0.44
B 2 2.94 0.35 34.3 3.58 1.34
  3 26.1 5.71 23.4 4.53 0.98
  4 4.90 3.72 11.3 5.22 1.90
  5 1.74 0.25 10.0 21.6 3.77
C 2 0.55 0.47 0.83 0.58 0.70
  3 1.32 0.94 1.04 1.89 0.93
  4 0.81 0.51 1.17 1.06 0.88
  5 0.41 0.34 0.70 0.53 0.46
D 2 0.42 0.35 0.77 0.48 0.57
  3 0.78 0.61 0.91 0.88 0.72
  4 0.38 0.27 0.98 0.43 0.59
  5 0.38 0.29 0.69 0.45 0.43
E 2 0.52 1.16 0.91 0.61 0.66
  3 1.28 1.53 1.07 1.15 0.98
  4 1.01 2.18 1.79 0.79 1.62
  5 0.38 0.32 0.72 0.45 0.45
F 2 0.51 0.85 0.99 0.56 0.97
  3 1.10 1.06 1.32 1.14 1.05
  4 1.58 2.67 3.11 1.08 2.85
  5 0.39 0.32 0.82 0.47 0.45
  1. Method A is the single-tissue compartment model with uncorrected and metabolite-corrected arterial plasma input functions. Method B is the two-tissue compartment model with uncorrected and metabolite-corrected arterial plasma input functions. Method C is the graphical plasma input model with metabolite-corrected arterial plasma input function. Method D is the graphical reference tissue model with a cerebellum time-activity curve. Method E is the reference tissue model with a cerebellum time-activity curve. Method F is the simplified reference tissue model with a cerebellum time-activity curve. Region 2 is the striatum, region 3 is the hippocampus, region 4 the is frontal lobe, and region 5 is the thalamus.