Skip to main content
EJNMMI Research

Table 1 Distribution volume of [N-methyl-11C]mirtazapine estimated using three methods

From: PET kinetics of radiolabeled antidepressant, [N-methyl-11C]mirtazapine, in the human brain

Method

Region

Subject

  

1

2

3

4

5

A

1

6.3

7.9

5.4

6.6

6.5

 

2

9.0

11.2

9.6

10.2

10.2

 

3

11.9

14.1

10.7

13.3

11.7

 

4

8.6

10.6

10.5

9.8

10.3

 

5

8.8

10.8

9.1

10.1

9.4

B

1

297.9

7.9

5.4

8.6

7.2

 

2

25.2

11.6

9.7

33.4

18.3

 

3

187.1

14.1

10.9

39.1

14.0

 

4

26.5

34.3

11.0

31.6

17.3

 

5

19.2

10.8

9.2

169.5

39.9

C

1

7.7

7.7

5.2

9.0

6.9

 

2

11.9

11.4

9.6

14.2

11.8

 

3

17.8

15.0

10.6

25.9

13.4

 

4

13.8

11.7

11.4

18.5

13.1

 

5

10.8

10.4

8.9

13.7

10.2

  1. Method A is the single-tissue compartment model with uncorrected and metabolite-corrected arterial plasma input functions. Method B is the two-tissue compartment model with uncorrected and metabolite-corrected arterial plasma input functions. Method C is the graphical plasma input model with metabolite-corrected arterial plasma input function. Region 1 is the cerebellum, region 2 is the striatum, region 3 is the hippocampus, region 4 is the frontal lobe, and region 5 is the thalamus.
Back to article page