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Table 1 Distribution volume of [N-methyl-11C]mirtazapine estimated using three methods

From: PET kinetics of radiolabeled antidepressant, [N-methyl-11C]mirtazapine, in the human brain

Method Region Subject
   1 2 3 4 5
A 1 6.3 7.9 5.4 6.6 6.5
  2 9.0 11.2 9.6 10.2 10.2
  3 11.9 14.1 10.7 13.3 11.7
  4 8.6 10.6 10.5 9.8 10.3
  5 8.8 10.8 9.1 10.1 9.4
B 1 297.9 7.9 5.4 8.6 7.2
  2 25.2 11.6 9.7 33.4 18.3
  3 187.1 14.1 10.9 39.1 14.0
  4 26.5 34.3 11.0 31.6 17.3
  5 19.2 10.8 9.2 169.5 39.9
C 1 7.7 7.7 5.2 9.0 6.9
  2 11.9 11.4 9.6 14.2 11.8
  3 17.8 15.0 10.6 25.9 13.4
  4 13.8 11.7 11.4 18.5 13.1
  5 10.8 10.4 8.9 13.7 10.2
  1. Method A is the single-tissue compartment model with uncorrected and metabolite-corrected arterial plasma input functions. Method B is the two-tissue compartment model with uncorrected and metabolite-corrected arterial plasma input functions. Method C is the graphical plasma input model with metabolite-corrected arterial plasma input function. Region 1 is the cerebellum, region 2 is the striatum, region 3 is the hippocampus, region 4 is the frontal lobe, and region 5 is the thalamus.