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Table 3 Defluorination rate in piglets between the deuterated and non-deuterated FE-DTBZ analogues (p < 0.05)

From: Decreased defluorination using the novel beta-cell imaging agent [18F]FE-DTBZ-d4 in pigs examined by PET

Parameter Unit Exp 1 Exp 2 Exp 3   Average SEM
[18F]FE-DTBZ
k defluorination a 1/min 0.015 0.0079 0.01214   0.012 0.002
t 1/2 min 46.2 87.7 57.1   63.4  
RSS   0.34 1.03 0.65    
[18F]FE-DTBZ-d4
k defluorination a 1/min 0.0016 0.00042 0.0035 0.00088 0.0016 0.0007
t 1/2 min 438.7 1650.4 197.5 787.7 433.9  
RSS   0.50 0.14 0.16 0.16   
  1. aThe rate constant k defluorination was almost 7.5 times lower after deuteration (0.0016 ± 0.0007 min-1 vs. 0.012 ± 0.002 min-1), resulting in an increased stability half-life (more than 6 h, up from 1 h). t 1/2, half-life; RSS, regression sum of squares; SEM, standard error of the mean.