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Table 2 Best fit parameters for describing the H TR for [18F]F- PK/PD in the cortical spinal bone

From: Decreased defluorination using the novel beta-cell imaging agent [18F]FE-DTBZ-d4 in pigs examined by PET

Parameter Unit Pig 1 Pig 2 Pig 3 Average SEM
K 1 a (cc/min)/cc 0.71 0.44 0.56 0.57 0.08
k 2 a 1/min 1.27 1.78 1.57 1.54 0.15
k 3 a 1/min 0.39 0.5 0.38 0.42 0.04
k 4 a 1/min 0.0061 0.0062 0.0051 0.0058 0.0004
V S b cc/cc 35.9 19.8 26.9 27.53 4.66
V T b cc/cc 36.4 20.1 27.2 27.9 4.72
V S/V T   0.99 0.99 0.99 0.99 0
Plasma delay s 25.6 23.5 27.9 25.67 1.27
Chi-square fit   0.43 0.41 0.29 0.38 0.04
  1. aRepresent the rate constants describing tracer flux between the blood plasma and the free/nonspecific tissue compartment (K 1 and k 2) as well as the flux into and out of the specific binding compartment (k 3 and k 4).bThe distribution volumes of the different compartments are expressed by V s (specific bound tracer) and V T (specific bound, nonspecific bound, and free tracers). SEM, standard error of the mean.