Decreased defluorination using the novel beta-cell imaging agent [18F]FE-DTBZ-d4 in pigs examined by PET

EJNMMI Research

Table 2 Best fit parameters for describing the H _TR for [¹⁸F]F^- PK/PD in the cortical spinal bone

Parameter	Unit	Pig 1	Pig 2	Pig 3	Average	SEM
K ₁ ^a	(cc/min)/cc	0.71	0.44	0.56	0.57	0.08
k ₂ ^a	1/min	1.27	1.78	1.57	1.54	0.15
k ₃ ^a	1/min	0.39	0.5	0.38	0.42	0.04
k ₄ ^a	1/min	0.0061	0.0062	0.0051	0.0058	0.0004
V _S ^b	cc/cc	35.9	19.8	26.9	27.53	4.66
V _T ^b	cc/cc	36.4	20.1	27.2	27.9	4.72
V _S/V _T		0.99	0.99	0.99	0.99	0
Plasma delay	s	25.6	23.5	27.9	25.67	1.27
Chi-square fit		0.43	0.41	0.29	0.38	0.04

^aRepresent the rate constants describing tracer flux between the blood plasma and the free/nonspecific tissue compartment (K ₁ and k ₂) as well as the flux into and out of the specific binding compartment (k ₃ and k ₄).^bThe distribution volumes of the different compartments are expressed by V _s (specific bound tracer) and V _T (specific bound, nonspecific bound, and free tracers). SEM, standard error of the mean.